Ultrasound-guided erector spinae plane block for postoperative analgesia in laparoscopic liver resection: A prospective, randomised controlled, patient and observer-blinded study.

Abstract

BACKGROUND:

Erector spinae plane block (ESPB) has been reported to manage postoperative pain effectively after various types of surgery. However, there has been a lack of study on the effect of ESPB after liver resection.

OBJECTIVES:

To investigate the analgesic effects of ESPB on pain control after laparoscopic liver resection compared with conventional pain management.

DESIGN:

Prospective, randomised controlled study.

SETTING:

A single tertiary care centre from February 2019 to February 2020.

PATIENTS:

A total of 70 patients scheduled to undergo laparoscopic liver resection.

INTERVENTIONS:

In the control group (n = 35), no procedure was performed. In the ESPB group (n = 35), ESPB was performed after induction of general anaesthesia. A total of 40 ml of ropivacaine 0.5% was injected at the T9 level bilaterally. After surgery, intravenous fentanyl patient-controlled analgesia was initiated. Fentanyl and hydromorphone were administered as rescue analgesics.

MAIN OUTCOME MEASURES:

The primary outcome was the cumulative postoperative opioid consumption at 24 h (morphine equivalent). The secondary outcomes were rescue opioid (fentanyl) dose in the postanaesthesia care unit (PACU) and pain severity at 1, 6, 12, 24, 48 and 72 h, assessed using a numerical rating scale (NRS) score.

RESULTS:

The median [IQR] postoperative opioid consumption during 24 hours following surgery was 48.2 [17.1] mg in the control group and 45.5 [35.8] mg in the ESPB group (median difference, 4.2 mg; 95% CI, -4.2 to 13.3 mg; P = 0.259). Conversely, rescue opioid in PACU was 5.3 [5.0] mg in the control group and 3.0 [1.5] mg in the ESPB group (median difference, 2.5 mg; 95% CI, 1.0 to 5.0 mg; P < 0.001). There was no significant difference in NRS scores point between the groups at any time.

CONCLUSION:

ESPB does not provide analgesic effect within 24 h after laparoscopic liver resection.

TRIAL REGISTRATION:

Clinical Trial Registry of Korea (https://cris.nih.go.kr.), identifier: KCT0003549).

• Authors: Doyeon Kim, Jong Man Kim, Gyu-Seong Choi, Gunyoung Heo, Gaab Soo Kim, Ji Seon Jeong
• Journal: European journal of anaesthesiology (Eur J Anaesthesiol) Vol. 38 Issue Suppl 2 Pg. S106-S112 (08 01 2021) ISSN: 1365-2346 [Electronic] England
• PMID: 33653982 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2021 European Society of Anaesthesiology and Intensive Care. Unauthorized reproduction of this article is prohibited.

Topics

• Analgesia, Patient-Controlled
• Humans
• Laparoscopy
• Liver
• Nerve Block
• Pain, Postoperative (diagnosis, etiology, prevention & control)
• Prospective Studies
• Republic of Korea
• Ultrasonography, Interventional