Senkyunolide I Protects against Sepsis-Associated Encephalopathy by Attenuating Sleep Deprivation in a Murine Model of Cecal Ligation and Puncture.

Abstract

Sepsis may lead to sleep deprivation, which will promote the development of neuroinflammation and mediate the progression of sepsis-associated encephalopathy (SAE). Senkyunolide I, an active component derived from an herb medicine, has been shown to provide a sedative effect to improve sleep. However, its role in sepsis is unclear. The present study was performed to investigate whether Senkyunolide I protected against SAE in a murine model of cecal ligation and puncture (CLP). Here, we showed that Senkyunolide I treatment improved the 7-day survival rate and reduced the excessive release of cytokines including TNF-α, IL-6, and IL-1β. A fear conditioning test was performed, and the results showed that Senkyunolide I attenuated CLP-induced cognitive dysfunction. Senkyunolide I treatment also decreased the phosphorylation levels of inflammatory signaling proteins, including p-ERK, p-JNK, p-P38, and p-P65, and the level of inflammatory cytokines, including TNF-α, IL-6, and IL-1β, in the hippocampus homogenate. Sleep deprivation was attenuated by Senkyunolide I administration, as demonstrated by the modification of the BDNF and c-FOS expression. When sleep deprivation was induced manually, the protective effect of Senkyunolide I against inflammatory responses and cognitive dysfunction was reversed. Our data demonstrated that Senkyunolide I could protect against sepsis-associated encephalopathy in a murine model of sepsis via relieving sleep deprivation.

• Authors: Jian Xie, Zhen-Zhen Zhao, Peng Li, Cheng-Long Zhu, Yu Guo, Jun Wang, Xiao-Ming Deng, Jia-Feng Wang
• Journal: Oxidative medicine and cellular longevity (Oxid Med Cell Longev) Vol. 2021 Pg. 6647258 ( 2021) ISSN: 1942-0994 [Electronic] United States
• PMID: 33628372 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Jian Xie et al.

Chemical References

• Anti-Inflammatory Agents
• Benzofurans
• Neuroprotective Agents
• senkyunolide I

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology, therapeutic use)
• Apoptosis (drug effects)
• Benzofurans (administration & dosage, chemistry, pharmacology, therapeutic use)
• Cecum (pathology)
• Cognitive Dysfunction (complications, drug therapy)
• Disease Models, Animal
• Hippocampus (drug effects, pathology)
• Inflammation (complications, pathology)
• Ligation
• Male
• Memory Disorders (complications, drug therapy)
• Mice, Inbred C57BL
• Microglia (drug effects, pathology)
• Neuroprotective Agents (pharmacology, therapeutic use)
• Punctures
• Sepsis-Associated Encephalopathy (complications, drug therapy, pathology)
• Signal Transduction (drug effects)
• Sleep Deprivation (complications, drug therapy, pathology)
• Survival Analysis
• Mice