Non-aspirin NSAID use and mortality of endometrial cancer. A nationwide cohort study.

Abstract

PURPOSE:

Laboratory studies have shown anti-neoplastic properties of non-aspirin NSAID; however, no studies have examined the influence of non-aspirin NSAIDs as potential adjuvant cancer therapy in women with endometrial cancer. We therefore examined the association between post-diagnostic use of non-aspirin NSAIDs and endometrial cancer mortality in Denmark.

METHODS:

We identified all women with a primary endometrial cancer diagnosis between 2000 and 2012, who were alive one year after the diagnosis. Information on drug use, cause-specific mortality and potential confounders was obtained from nationwide health- and demographic registries. Cox regression models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between post-diagnostic non-aspirin NSAID use and endometrial cancer mortality.

RESULTS:

Among 6 694 endometrial cancer patients with a maximum follow-up of 13 years, 753 women died from endometrial cancer. Post-diagnostic non-aspirin NSAID use (≥ 1 filled prescription) was associated with an overall HR of 1.15 (95% CI; 0.97-1.36) for endometrial cancer mortality, with higher HRs for the highest intensity of use (HR; 1.40, 95% CI; 1.11-1.77) and largest cumulative amount (HR; 1.56, 95% CI; 1.14-2.14).

CONCLUSION:

Our findings yielded no evidence that use of non-aspirin NSAIDs was associated with reduced endometrial cancer. Rather, we observed that high-intensity and large cumulative amount of non-aspirin NSAID use may be associated with increased endometrial cancer mortality.

• Authors: Cecilie Dyg Sperling, Freija Verdoodt, Gitte Lerche Aalborg, Christian Dehlendorff, Søren Friis, Susanne K Kjaer
• Journal: Cancer causes & control : CCC (Cancer Causes Control) Vol. 32 Issue 5 Pg. 515-523 (May 2021) ISSN: 1573-7225 [Electronic] Netherlands
• PMID: 33620641 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal

Topics

• Adult
• Aged
• Aged, 80 and over
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Cohort Studies
• Endometrial Neoplasms (mortality)
• Female
• Humans
• Middle Aged
• Proportional Hazards Models
• Registries