Salivary CCL20 Level as a Biomarker for Oral Squamous Cell Carcinoma.

Abstract

BACKGROUND/AIM:

This study investigated the utility of C-C motif chemokine ligand 20 (CCL20) expression in saliva as a biomarker for oral squamous cell carcinoma (OSCC) and also examined the associated microbiome.

MATERIALS AND METHODS:

The study group included patients with OSCC or oral potentially malignant disorder (OPMD), and healthy volunteers (HVs). microarray and qRT-PCR were used to compare salivary CCL20 expression levels among groups. Data on CCL20 levels in oral cancer tissues and normal tissues were retrieved from a public database and examined. Furthermore, next-generation sequencing was used to investigate the salivary microbiome.

RESULTS:

A significant increase in the expression level of CCL20 was observed in both OSCC tissues and saliva from patients with oral cancer. Fusobacterium was identified as the predominant bacteria in OSCC and correlated with CCL20 expression level. OSCC screening based on salivary CCL20 expression enabled successful differentiation between patients with OSCC and HVs.

CONCLUSION:

CCL20 expression may be a useful biomarker for OSCC.

• Authors: Sei Ueda, Mitsuo Goto, Kengo Hashimoto, Shogo Hasegawa, Masahiko Imazawa, Marico Takahashi, Ichiro Oh-Iwa, Kazuo Shimozato, Toru Nagao, Shuji Nomoto
• Journal: Cancer genomics & proteomics (Cancer Genomics Proteomics) 2021 Mar-Apr Vol. 18 Issue 2 Pg. 103-112 ISSN: 1790-6245 [Electronic] Greece
• PMID: 33608307 (Publication Type: Journal Article, Review)
• Copyright: Copyright© 2021, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Biomarkers, Tumor
• CCL20 protein, human
• Chemokine CCL20

Topics

• Biomarkers, Tumor (metabolism)
• Carcinoma, Squamous Cell (diagnosis)
• Case-Control Studies
• Chemokine CCL20 (metabolism)
• Female
• Humans
• Male
• Middle Aged
• Mouth Neoplasms (diagnosis)