Abstract | BACKGROUND: METHODS: A genome-wide circular RNA expression analysis was performed in blood of genetically diagnosed patients with Fabry disease (n=58), age-matched and sex-matched healthy volunteers (n=14) and disease control patients with acute kidney injury (n=109). Most highly dysregulated circular RNAs were validated by quantitative real-time PCR. Circular RNA biomarker sensitivity, specificity, predictive values and area under the curve (AUC) were determined. Linear regression analyses were conducted for validated circular RNA biomarkers and clinical patient characteristics. RESULTS: CONCLUSION:
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Authors | Albina Nowak, George Haddad, Andreas D Kistler, Stellor Nlandu-Khodo, Felix Beuschlein, Rudolf P Wüthrich, Johan M Lorenzen, Malte Kölling |
Journal | Journal of medical genetics
(J Med Genet)
Vol. 59
Issue 3
Pg. 279-286
(03 2022)
ISSN: 1468-6244 [Electronic] England |
PMID | 33547137
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ. |
Chemical References |
- Biomarkers
- Biomarkers, Tumor
- RNA, Circular
- RNA
- Galactosidases
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Topics |
- Acute Kidney Injury
- Biomarkers
(metabolism)
- Biomarkers, Tumor
- Fabry Disease
(diagnosis, genetics)
- Female
- Galactosidases
(genetics)
- Humans
- Male
- Phenotype
- RNA
(genetics, metabolism)
- RNA, Circular
(genetics)
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