Long-term efficacy of triple semicircular canal plugging in the treatment of patients with ipsilateral delayed endolymphatic hydrops.

Abstract

This study aims to explore the long-term efficacy of triple semicircular canal plugging (TSCP) in the treatment of intractable ipsilateral delayed endolymphatic hydrops (DEH), so as to provide an alternative therapy for this disease. Forty-eight patients diagnosed with ipsilateral DEH referred to vertigo clinic of our hospital between Dec. 2010 and Dec. 2017, were included in this study for retrospective analysis. All patients were followed up for 2 years. Vertigo control and auditory functions were measured and analyzed. Pure tone audiometry, caloric test, and vestibular evoked myogenic potential (VEMP) were performed in two-year follow-up. Forty-five patients who accepted intratympanic gentamicin (26.7 mg/mL) twice given one week apart were selected as a control group. The total control rate of vertigo in TSCP group was 97.9% (47/48) in the two-year follow-up, with complete control rate of 83.3% (40/48) and substantial control rate of 14.6% (7/48). The rate of hearing loss was 22.9% (11/48). The total control rate of vertigo in intratympanic gentamicin group was 80.0% (36/45), with complete control rate of 57.8% (26/45) and substantial control rate of 22.2% (10/45), and the rate of hearing loss was 20.0% (9/45). The vertigo control rate of TSCP was significantly higher than that of intratympanic gentamicin (χ2 = 6.01, p < 0.05). There was no significant difference of hearing loss rate between two groups. (χ2 = 0.12, p > 0.05). TSCP, which can reduce vertiginous symptoms in patients with intractable ipsilateral DEH, represents an effective therapy for this disorder.

• Authors: Daogong Zhang, Yafeng Lv, Xiaofei Li, Yawei Li, Yongdong Song, Zhaomin Fan, Haibo Wang
• Journal: Scientific reports (Sci Rep) Vol. 11 Issue 1 Pg. 3156 (02 04 2021) ISSN: 2045-2322 [Electronic] England
• PMID: 33542390 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Gentamicins

Topics

• Anti-Bacterial Agents (therapeutic use)
• Audiometry, Pure-Tone
• Complementary Therapies (methods)
• Endolymphatic Hydrops (diagnostic imaging, drug therapy, pathology, surgery)
• Female
• Gentamicins (therapeutic use)
• Hearing Loss, Sensorineural (diagnostic imaging, drug therapy, pathology, surgery)
• Humans
• Injection, Intratympanic
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Retrospective Studies
• Semicircular Canals (diagnostic imaging, drug effects, pathology, surgery)
• Treatment Outcome
• Vertigo (diagnostic imaging, drug therapy, pathology, surgery)
• Vestibular Evoked Myogenic Potentials (drug effects, physiology)