Association of SLC6A4 methylation with long-term outcomes after stroke: focus on the interaction with suicidal ideation.
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| Abstract |
Serotonin (5-HT) plays an important role in cerebrovascular homeostasis and psychiatric disorders, including suicidality. Methylation of the serotonin transporter gene (SLC6A4) is associated with 5-HT expression. However, the prognostic roles of SLC6A4 methylation and suicidal ideation (SI) in long-term outcomes of stroke have not been evaluated. We investigated the independent and interactive effects of SLC6A4 methylation and SI immediately after stroke on long-term outcomes. Blood SLC6A4 methylation status and SI based on the suicide item of the Montgomery-Åsberg Depression Rating Scale were assessed in 278 patients at 2 weeks after stroke. After the index stroke, cerebro-cardiovascular events by SLC6A4 methylation status and SI were investigated over an 8-14-year follow-up period and using Cox regression models adjusted for a range of covariates. SLC6A4 hypermethylation and SI within 2 weeks of stroke both predicted worse long-term outcomes, independent of covariates. A significant interaction effect of SI and the methylation status of CpG 4 on long-term stroke outcomes was also identified. The association between SLC6A4 methylation and long-term adverse outcomes may be strengthened in the presence of SI within 2 weeks after stroke. Evaluation of methylation and SI status during the acute phase can be helpful when assessing stroke patients.
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| Authors | Hee-Ju Kang, Eun-Hye Lee, Ju-Wan Kim, Sung-Wan Kim, Il-Seon Shin, Joon-Tae Kim, Man-Seok Park, Ki-Hyun Cho, Jung-Soo Han, In Kyoon Lyoo, Jae-Min Kim |
| Journal | Scientific reports (Sci Rep) Vol. 11 Issue 1 Pg. 2710 (02 01 2021) ISSN: 2045-2322 [Electronic] England |
| PMID | 33526821 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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