Vaccines are one of utmost important weapons in modern medicine to fight a wide range of diseases. To achieve optimal vaccination effects, repeated
injections of
vaccines are often required, which would largely decrease patient comfort. Herein, an ultrasound-responsive self-healing
hydrogel system loaded with
nanovaccines is designed for remotely controlled
tumor vaccine release and individualized
cancer immunotherapy. The gel could be transformed into
sol status in response to ultrasound treatment, allowing a burst release of
nanovaccines, and self-healed to gel afterward. For mice with a single
subcutaneous injection of
nanovaccine-loaded gel and multiple ultrasound treatments, repeatedly released
nanovaccines could elicit antitumor immune responses, which in combination with
immune checkpoint blockade could effectively inhibit established
tumors, and prevent postoperative
tumor metastases and recurrence based on our personalized
nanovaccine system. This work presents an easy-to-operate strategy to realize controllable and durable delivery of
vaccines against
cancer and potentially other types of diseases.