Abstract | HYPOTHESIS: BACKGROUND: METHODS: Eighteen healthy female Wistar albino rats weighing 250āg were chosen for the study. The animals were divided into two groups: group 1 received montelukast and group 2 was the control group. Intratympanic propylene glycol injection was administered into the left ears and physiologic serum was instilled into the right ears of the animals on the first, eighth, and fifteenth days. The effects of montelukast administration were evaluated by histological examination of the tympanic membrane and middle ear. RESULTS: Group 1 ( montelukast group) showed significant differences in terms of cholesteatoma formation, granulation, epithelial invagination, and inflammation. Cholesteatoma formation in the left ear was observed in 2 (22%) and 8 (89%) rats in groups 1 and 2, respectively (pā=ā0.015). CONCLUSION:
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Authors | Ramazan Ocal, Selda Kargin Kaytez, Nihat Yumusak, Ozlem Akkoca, Hatice Celik, Necmi Arslan |
Journal | Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
(Otol Neurotol)
Vol. 42
Issue 5
Pg. e568-e572
(06 01 2021)
ISSN: 1537-4505 [Electronic] United States |
PMID | 33481545
(Publication Type: Journal Article)
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Copyright | Copyright © 2021, Otology & Neurotology, Inc. |
Chemical References |
- Acetates
- Cyclopropanes
- Quinolines
- Sulfides
- montelukast
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Topics |
- Acetates
- Animals
- Cholesteatoma, Middle Ear
- Cyclopropanes
- Female
- Inflammation
(drug therapy)
- Models, Animal
- Quinolines
- Rats
- Rats, Wistar
- Sulfides
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