Effects of Zoniporide and BMA-1321 Compound on the Rate of Oxygen Absorption by Cardiomyocyte Mitochondria in Rats with Experimental Chronic Heart Failure.

Abstract

Uncoupling of respiration and ATP production by myocardial mitochondria was observed in rats with chronic isoproterenol intoxication (L-isoproterenol subcutaneously, 1 mg/kg, for 10 days) in comparison with controls (injected with the solvent). Inhibitors of NHE-1 zoniporide (1 mg/kg intraperitoneally, 13 days) and BMA-1321 compound (0.92 mg/kg intraperitoneally, 13 days) improved the mitochondrial function in rats with isoproterenol-induced cardiac failure: respiratory control coefficients increased, more so for the respiratory chain complex II, the main source of ROS in heart failure. The effect of BMA-1321 was more manifest (53%; p<0.05) in comparison with zoniporide (35%; p<0.05).

• Authors: A A Spasov, N A Gurova, T A Popova, V N Perfilova, V V Vishnevskaya, M V Kustova, N V Ovsyankina, A A Ozerov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 170 Issue 3 Pg. 316-320 (Jan 2021) ISSN: 1573-8221 [Electronic] United States
• PMID: 33452978 (Publication Type: Journal Article)

Chemical References

• Guanidines
• Pyrazoles
• Reactive Oxygen Species
• zoniporide
• Isoproterenol

Topics

• Animals
• Female
• Guanidines (therapeutic use)
• Heart Failure (drug therapy)
• Isoproterenol (therapeutic use)
• Mitochondria, Heart (drug effects, metabolism)
• Models, Biological
• Myocytes, Cardiac (drug effects, metabolism)
• Pyrazoles (therapeutic use)
• Rats
• Reactive Oxygen Species (metabolism)