Abstract | BACKGROUND: METHODS: This case control study was based on routinely collected clinical data. Participants included women who had undergone cesarean section and adopted a patient-controlled analgesia pump for postoperative analgesia. A series of logistic regression analyses were performed. Interaction terms were added to explore the moderation effects of combined local anesthetics and pain level on associations between morphine concentration and pruritus. Robustness of the results was checked through sensitivity analysis using propensity scores matching approach. RESULTS: Higher morphine concentration, assisted reproductive treatment, and multipara and cesarean section history were significantly more prevalent in the pruritus group than in the control group. The probabilities of pruritus at morphine concentrations of 10, 15, 20, 25, 30 and 40 μg/mL increased sequentially from 0.05, 0.1, 0.2, 0.35, 0.54 to 0.84, respectively. The trend remained steep in the ropivacaine stratum and became flatter when combined with levobupivacaine. At mild pain combined with levobupivacaine, the incidence of pruritus increased from 0.33 (95% confidence interval [CI] 0.1-0.68) in the 10 μg/mL morphine group to 0.48 (95% CI 0.1-0.88) in the 40 μg/mL morphine group. In the stratum of moderate pain combined with levobupivacaine, the incidence increased from 0.4 (95% CI 0.04-0.92) to 0.56 (95% CI 0.03-0.98). The results in the sensitivity analysis were in consistent with above findings. CONCLUSIONS:
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Authors | Xinyi Tian, Kaifan Niu, Hong Cao, Gonghao Zhan, Yan Zhang, Feng Xu, Wangning Shangguan, Ye Gao |
Journal | BMC pregnancy and childbirth
(BMC Pregnancy Childbirth)
Vol. 21
Issue 1
Pg. 60
(Jan 15 2021)
ISSN: 1471-2393 [Electronic] England |
PMID | 33451285
(Publication Type: Journal Article, Observational Study)
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Chemical References |
- Analgesics, Opioid
- Morphine
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Topics |
- Adult
- Analgesia, Epidural
- Analgesia, Obstetrical
- Analgesics, Opioid
(administration & dosage, adverse effects)
- Case-Control Studies
- Cesarean Section
- Dose-Response Relationship, Drug
- Female
- Humans
- Morphine
(administration & dosage, adverse effects)
- Pain
(drug therapy)
- Pain Management
- Pregnancy
- Pruritus
(chemically induced)
- Risk Factors
- Young Adult
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