Changes in choroidal imaging parameters following adalimumab therapy for refractory noninfectious uveitis.

Abstract

PURPOSE:

To evaluate the short-term change in choroidal structure following adalimumab (ADA) treatment in refractory noninfectious uveitis.

METHODS:

This was a retrospective study of 33 eyes from 18 patients with refractory noninfectious uveitis. Subfoveal choroidal thickness (SFCT), the choroidal stromal index (CSI) defined as the proportion of stromal area to the total choroidal area were used as choroidal imaging parameters and were evaluated by enhanced depth imaging optical coherence tomography (EDI-OCT). The change in these parameters in the 2 months following initiation of ADA was analysed. A linear mixed-effect model was used to assess the effect of ADA treatment.

RESULTS:

The causes of uveitis were Vogt-Koyanagi-Harada disease (VKHD) (42.4%), presumed autoimmune retinopathy (15.2%), others (12.1%) and unclassified (30.3%). In the analysis of all eyes, the SFCT was 309.7 ± 113.1 μm at baseline, 295.7 ± 114.5 μm at 1 month and 275.2 ± 98.8 μm at 2 months after ADA initiation (P < 0.001). The CSI was 0.275 ± 0.050 at baseline, 0.273 ± 0.068 at 1 month and 0.273 ± 0.046 at 2 months (P = 0.785). In the subgroup analysis, the SFCT decreased significantly from baseline to 2 months in VKHD eyes (P = 0.007) and unclassified eyes (P = 0.034). There was no significant change in CSI in either subgroup.

CONCLUSIONS:

In the assessment of short-term response to ADA treatment in uveitic eyes, using EDI-OCT, the SFCT appears to be more effective as a choroidal imaging biomarker than the CSI, especially in VKHD eyes.

• Authors: Ryuto Nishisho, Sentaro Kusuhara, Noriyuki Sotani, Kyong Woo Kim, Atsuko Katsuyama-Yoshikawa, Wataru Matsumiya, Kengo Akashi, Akio Morinobu, Makoto Nakamura
• Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (Graefes Arch Clin Exp Ophthalmol) Vol. 259 Issue 5 Pg. 1273-1280 (May 2021) ISSN: 1435-702X [Electronic] Germany
• PMID: 33415356 (Publication Type: Journal Article)

Chemical References

• Adalimumab

Topics

• Adalimumab
• Autoimmune Diseases
• Choroid
• Fluorescein Angiography
• Humans
• Retinal Diseases
• Retrospective Studies
• Tomography, Optical Coherence
• Uveitis (diagnosis, drug therapy)