Abstract | OBJECTIVES: To investigate the prevalence, distribution and predictive value for the development of inflammatory arthritis (IA) of conventional radiography (CR) bone erosions (BE) in anti-CCP positive (CCP+) at-risk individuals with musculoskeletal (MSK) symptoms but without clinical synovitis. METHODS: Baseline CR of the hands and feet of 418 CCP+ at-risk individuals were analysed. The presence of US-BE was explored in the anatomical areas in which CR-BE were reported. Hands and feet CR at the time of progression were analysed in a subset of individuals who developed IA (73/123, 59.3%). Logistic regression analyses were performed to calculate the predictive value of baseline CR-BE for the development of IA in 394 CCP+ individuals with ≥1 follow-up visit. RESULTS: BE were detected in 17/418 (4.1%) CCP+ at-risk individuals (median Simple Erosions Narrowing Score-BE = 2.0, IQR: 1.0-2.0; median Sharp van der Heijde score-BE = 4.0, IQR: 3.0-8.5), most frequently in the foot joints (11/17, 64.7% individuals). A total of 123/394 (31.2%) CCP+ at-risk individuals developed IA; 7/17 (41.2%) with, and 116/377 (30.8%) without BE on CR (P = 0.37). US-BE were found in 4/7 (57.1%) individuals with CR-BE who developed IA, but only in 1/10 (10.0%) who did not. At the time of progression, new BE were detected in 4/73 (5.5%) CCP+ individuals on repeated CR. In the regression analyses, baseline CR-BE were not predictive for the development of IA. CONCLUSIONS: In CCP+ at-risk individuals with MSK symptoms, CR-detected BE are uncommon and do not predict the development of IA.
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Authors | Andrea Di Matteo, Kulveer Mankia, Jacqueline L Nam, Edoardo Cipolletta, Leticia Garcia-Montoya, Laurence Duquenne, Emma Rowbotham, Paul Emery |
Journal | Rheumatology (Oxford, England)
(Rheumatology (Oxford))
Vol. 60
Issue 7
Pg. 3156-3164
(07 01 2021)
ISSN: 1462-0332 [Electronic] England |
PMID | 33415335
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: [email protected]. |
Chemical References |
- Anti-Citrullinated Protein Antibodies
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Topics |
- Adult
- Anti-Citrullinated Protein Antibodies
(immunology)
- Arthritis, Rheumatoid
(diagnostic imaging, epidemiology, immunology)
- Bone and Bones
(diagnostic imaging)
- Disease Progression
- Female
- Foot Joints
(diagnostic imaging)
- Hand Joints
(diagnostic imaging)
- Humans
- Male
- Middle Aged
- Radiography
- Risk
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