Interleukin-35: An emerging player in the progression of liver diseases.

Abstract

Interleukin-35(IL-35), a newly identified immunosuppressive cytokine, has recently been shown to play a significant role in the progression of various autoimmune diseases and malignant tumors. The liver is the largest organ in the body and is generally regarded as an important lymphoid organ by an increasing number of immunologists. A number of reports have demonstrated that IL-35 plays essential roles in maintaining the immune homeostasis of the liver microenvironment. This review summarizes the existing studies of IL-35 in liver diseases, including viral hepatitis, immune liver injury, liver cirrhosis and carcinoma. We aimed to provide a comprehensive overview of the vital roles of IL-35 in hepatic damage and explore new alternative therapeutic targets for these diseases.

• Authors: Na Zhao, Xin Liu, Hao Guo, Xiangnan Zhao, Yujie Qiu, Wei Wang
• Journal: Clinics and research in hepatology and gastroenterology (Clin Res Hepatol Gastroenterol) Vol. 45 Issue 1 Pg. 101518 (Jan 2021) ISSN: 2210-741X [Electronic] France
• PMID: 33387857 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2020 Elsevier Masson SAS. All rights reserved.

Chemical References

• Cytokines
• Interleukins

Topics

• Cytokines
• Humans
• Interleukins
• Liver (pathology)
• Liver Cirrhosis (pathology)
• Liver Diseases