Effect of intravenous application of nicorandil on area of myocardial infarction in patients with STEMI during the perioperative stage of PCI.

Abstract

OBJECTIVE:

The aim of the present study was to evaluate the effectiveness and safety of nicorandil in improving the area of myocardial infarction in patients with acute myocardial infarction (AMI).

METHODS:

One hundred and twenty patients with acute ST-segment elevation myocardial infarction (STEMI) admitted to our hospital between December 1, 2018 and December 31, 2019 were selected and randomly allocated to the experimental group (group A, n = 60) and the control group (group B, n = 60). In the experimental group, an infusion of nicorandil was given intravenously before the first balloon dilation or 1 minute before the stent placement, and with the completion of the infusion, nicorandil maintenance infusion was given. In the control group, only balloon dilation and stent placement were undertaken.

RESULTS:

The postoperative peak levels of myoglobin, creatine kinase isoform and hypersensitive troponin T were significantly lower in group A than in group B (p < 0.05). Moreover, the left ventricular ejection fraction (LVEF) on the 180th day post operation was substantially greater in group A than in group B (p < 0.01), and the area of myocardial infarction was significantly smaller in patients in group A than those in group B on the 180th day post operation (p < 0.01). In terms of the safety, there were no statistically significant differences in the incidence of slow flow/no reflow, malignant arrhythmias, and hypotension within 24 hours post operation between the two groups (p > 0.05), and no major adverse cardiovascular event (MACE) occurred in either group during the postoperative follow-up period of 180 days (p > 0.05).

CONCLUSION:

Intravenous administration of nicorandil in patients with STEMI during the perioperative percutaneous coronary intervention (PCI) period was effective in reducing the area of myocardial infarction and myocardial injury without increasing the incidence of malignant arrhythmias, hypotension, or composite cardiovascular events during the drug administration period.

• Authors: Zheng-Dong Wang, Hao Li, Ming Liu, Ping Li, Jian Chen, Xiang-Wen Liang, Xian-Zhang Zhu, Wang Liao
• Journal: Clinical hemorheology and microcirculation (Clin Hemorheol Microcirc) Vol. 77 Issue 4 Pg. 411-423 ( 2021) ISSN: 1875-8622 [Electronic] Netherlands
• PMID: 33386796 (Publication Type: Journal Article)

Chemical References

• Antihypertensive Agents
• Nicorandil

Topics

• Administration, Intravenous (methods)
• Antihypertensive Agents (pharmacology, therapeutic use)
• Female
• Humans
• Male
• Middle Aged
• Nicorandil (pharmacology, therapeutic use)
• Percutaneous Coronary Intervention (methods)
• Perioperative Period
• ST Elevation Myocardial Infarction (drug therapy)
• Treatment Outcome