Vascular Endothelial Growth Factor-A Is Associated with Platelets and Complement 4 in Patients with Primary Sjögren's Syndrome.

Abstract

OBJECTIVE:

We aimed at investigating the expression level of vascular endothelial growth factor-A (VEGF-A) in patients with primary Sjögren's Syndrome (pSS) and evaluating the relationship between serum VEGF-A and the laboratory indicators that are associated with it in pSS.

METHODS:

The VEGF-A levels were measured by ELISA in a total of 88 participants, including 58 patients with pSS and 30 healthy people. The VEGF-A levels between two groups were analyzed.

RESULTS:

The serum levels of VEGF-A in pSS and control groups were 175.50 (112.00,296.50) pg/mL and 181.50 (155.25,288.50) pg/mL, without statistically significant difference. The associations were found between serum levels of VEGF-A with C reactive protein (CRP) (r=0.265, P<0.05), white blood cells (WBC) (r=0.302, P<0.05), neutrophils (NEUT) (r=0.349, P<0.05), platelets(PLT) (r=0.276, P<0.05), complement 3 (C3) (r=0.477, P<0.05), complement 4 (C4) (r=0.387, P<0.05) and CA19-9 (r=0.392, P<0.05). Among these laboratory indicators, VEGF-A was correlated with platelets and complement 4 in patients with pSS.

CONCLUSIONS:

In patients with pSS, the levels of VEGF-A were independently influenced by the levels of platelet and complement 4, which indicated the intermodulation between the growth factor and immune system in the autoimmune disease.

• Authors: Zi-Yan Huang, Yi-Ru Yuan, Yue-Le Kong, Ting Zhang, Yan Liang
• Journal: Annals of clinical and laboratory science (Ann Clin Lab Sci) Vol. 50 Issue 6 Pg. 790-796 (Nov 2020) ISSN: 1550-8080 [Electronic] United States
• PMID: 33334795 (Publication Type: Journal Article)
• Copyright: © 2020 by the Association of Clinical Scientists, Inc.

Chemical References

• Complement C4
• VEGFA protein, human
• Vascular Endothelial Growth Factor A
• C-Reactive Protein

Topics

• Adult
• Aged
• Blood Platelets (metabolism)
• C-Reactive Protein (metabolism)
• Case-Control Studies
• China
• Complement C4 (analysis, metabolism)
• Female
• Humans
• Leukocytes (metabolism)
• Male
• Middle Aged
• Sjogren's Syndrome (immunology, metabolism, physiopathology)
• Vascular Endothelial Growth Factor A (blood, metabolism, physiology)