Peripheral IGF-1 in bipolar disorder and major depressive disorder: a systematic review and meta-analysis.

Abstract

BACKGROUND:

In recent years, a number of studies have shown abnormal levels of peripheral insulin growth factor-1 (IGF-1) in patients with mood disorder, but the results are not uniform. Therefore, this paper focuses on such studies, conducts a systematic review and meta-analysis, and discusses the factors affecting peripheral IGF-1 in patients with mood disorder.

METHODS:

Cochrane database, PubMed database, Embase database, CNKI database, Wanfang Database and Weipu database were searched by computer. The retrieval time was from June 2020 to search for a controlled study of the relationship between bipolar disorder (BD) or major depressive disorder and normal control peripheral IGF-1. Review Manager (version 5.3) software was used for meta-analysis.

RESULTS:

A total of 14 articles in Chinese and English were included; 285 patients with BD and 503 patients with major depressive disorder. Meta-analysis showed that in comparison with the control group, IGF-1 levels in peripheral blood of patients with BD (MD =67.66, 95% CI: 7.01-128.31, P=0.03) and major depressive disorder (MD =8.01, 95% CI: 3.43-12.58, P=0.0006) were significantly increased. In the meta-analysis comparing the peripheral IGF-1 levels of patients before and after treatment, the results showed no significant change in the peripheral IGF-1 level before and after treatment (P=0.53).

CONCLUSIONS:

High peripheral IGF-1 level is a related factor of BD and major depressive disorder, although this needs to be confirmed by further large sample studies.

• Authors: Mengyi Chen, Lei Zhang, Qi Jiang
• Journal: Annals of palliative medicine (Ann Palliat Med) Vol. 9 Issue 6 Pg. 4044-4053 (Nov 2020) ISSN: 2224-5839 [Electronic] China
• PMID: 33302664 (Publication Type: Journal Article, Meta-Analysis, Systematic Review)

Chemical References

• Insulin
• Insulin-Like Growth Factor I

Topics

• Bipolar Disorder
• Databases, Factual
• Depressive Disorder, Major
• Humans
• Insulin
• Insulin-Like Growth Factor I