Improvement of magnesium isoglycyrrhizinate on DSS-induced acute and chronic colitis.

Abstract

Inflammatory bowel disease (IBD) is a worldwide prototypical complex disease, owing to its multifactorial causes, relapsing and remitting condition and high incidence. Thus, effective therapeutic approaches need to be developed for patients with IBD. Currently, we reported the improving effect of magnesium isoglycyrrhizinate on colitis induced by dextran sulfate sodium (DSS). We found that magnesium isoglycyrrhizinate treatment significantly alleviated DSS-induced acute and chronic colitis by inhibiting the inflammatory response characterized by reduce of the infiltrations of immune cell and the level of pro-inflammatory cytokines. Besides, magnesium isoglycyrrhizinate treatment significantly inhibited the level of ROS and decreased the gut barrier destruction after DSS treatment. Furthermore, the results also showed that administration of magnesium isoglycyrrhizinate significantly reduced the colonic fibrosis. Taken together, these results revealed the potency of magnesium isoglycyrrhizinate on the intestinal inflammation, by which points to the possible use of magnesium isoglycyrrhizinate for IBD therapy in clinical applications.

• Authors: Jian Cui, Yan Li, Chenyang Jiao, Jianhua Gao, Yingxue He, Beibei Nie, Lingdong Kong, Wenjie Guo, Qiang Xu
• Journal: International immunopharmacology (Int Immunopharmacol) Vol. 90 Pg. 107194 (Jan 2021) ISSN: 1878-1705 [Electronic] Netherlands
• PMID: 33290965 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Elsevier B.V. All rights reserved.

Chemical References

• 18alpha,20beta-hydroxy-11-oxo-norolean-12-en-3beta-yl-2-O-beta-D-glucopyranurosyl-alpha-D-glucopyranosiduronate magnesium tetrahydrate
• Anti-Inflammatory Agents
• Cytokines
• Inflammation Mediators
• Reactive Oxygen Species
• Saponins
• Tight Junction Proteins
• Triterpenes
• Dextran Sulfate

Topics

• Acute Disease
• Animals
• Anti-Inflammatory Agents (pharmacology)
• Chronic Disease
• Colitis (chemically induced, metabolism, pathology, prevention & control)
• Colon (drug effects, metabolism, pathology)
• Cytokines (genetics, metabolism)
• Dextran Sulfate
• Disease Models, Animal
• Female
• Fibrosis
• Inflammation Mediators (metabolism)
• Intestinal Mucosa (drug effects, metabolism, pathology)
• Mice, Inbred C57BL
• Permeability
• Reactive Oxygen Species (metabolism)
• Saponins (pharmacology)
• Tight Junction Proteins (genetics, metabolism)
• Tight Junctions (drug effects, metabolism, pathology)
• Triterpenes (pharmacology)