Abstract | BACKGROUND: METHODS: Hospital-based (n = 89) and population-based (2,921 cases and 11,684 controls) Taiwanese UTUC cohorts were used to investigate the association between exposure to AA and/or arsenic and the risk of developing UTUC. In the hospital cohort, AA exposure was evaluated by measuring aristolactam- DNA adducts in the renal cortex and by identifying A>T TP53 mutations in tumors. In the population cohort, AA exposure was determined from prescription health insurance records. Arsenic levels were graded from 0 to 3 based on concentrations in well water and the presence of arseniasis-related diseases. RESULTS: In the hospital cohort, 43, 26, and 20 patients resided in grade 0, 1+2, and 3 arseniasis-endemic areas, respectively. Aristolactam- DNA adducts were present in >90% of these patients, indicating widespread AA exposure. A>T mutations in TP53 were detected in 28%, 44%, and 22% of patients residing in grade 0, 1+2, and 3 arseniasis-endemic areas, respectively. Population studies revealed that individuals who consumed more AA-containing herbs had a higher risk of developing UTUC in both arseniasis-endemic and nonendemic areas. Logistic regression showed an additive effect of AA and arsenic exposure on the risk of developing UTUC. CONCLUSIONS: Exposure to both AA and arsenic acts additively to increase the UTUC risk in Taiwan. IMPACT: This is the first study to investigate the combined effect of AA and arsenic exposure on UTUC.
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Authors | Chung-Hsin Chen, Arthur P Grollman, Chao-Yuan Huang, Chia-Tung Shun, Viktoriya S Sidorenko, Keiji Hashimoto, Masaaki Moriya, Robert J Turesky, Byeong Hwa Yun, Karen Tsai, Stephanie Wu, Po-Ya Chuang, Chao-Hsiun Tang, Wen-Horng Yang, Tzong-Shin Tzai, Yuh-Shyan Tsai, Kathleen G Dickman, Yeong-Shiau Pu |
Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
(Cancer Epidemiol Biomarkers Prev)
Vol. 30
Issue 2
Pg. 317-325
(02 2021)
ISSN: 1538-7755 [Electronic] United States |
PMID | 33277322
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | ©2020 American Association for Cancer Research. |
Chemical References |
- Aristolochic Acids
- DNA Adducts
- Arsenic
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Topics |
- Aged
- Aristolochic Acids
(toxicity)
- Arsenic
(toxicity)
- Carcinoma, Transitional Cell
(chemically induced, epidemiology, genetics, pathology)
- Case-Control Studies
- DNA Adducts
- Female
- Humans
- Incidence
- Male
- Neoplasm Grading
- Taiwan
(epidemiology)
- Urinary Bladder Neoplasms
(chemically induced, epidemiology, genetics, pathology)
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