Abstract | INTRODUCTION: Continuous glucose monitoring (CGM) provides detailed information about glucose level fluctuations over time. The method is increasingly being used in pregnant women with type 1 diabetes. However, only one previous study compared CGM results related to pregnancy outcomes in women using insulin pumps with those administering multiple daily injections (MDI). We performed a secondary analysis of CGM metrics from an observational cohort of pregnant women with type 1 diabetes and compared insulin pump and MDI therapies in relation to maternal and neonatal outcomes. MATERIAL AND METHODS: The study included 185 pregnant Swedish women with type 1 diabetes undergoing CGM throughout pregnancy. Women were divided according to insulin administration mode, ie MDI (n = 131) or pump (n = 54). A total of 91 women used real-time CGM and 94 women used intermittently viewed CGM. Maternal demographics and maternal and neonatal outcome data were collected from medical records. CGM data were analyzed according to predefined glycemic indices: mean glucose; standard deviation; percentage of time within, below and above glucose target range; mean amplitude of glycemic excursion; high and low glucose indices; and coefficient variation in percent. Associations between insulin administration mode and CGM data, on the one hand, and maternal and neonatal outcomes, on the other, were analyzed with analysis of covariance and logistic regression, respectively, adjusted for confounders. RESULTS: There were no differences in maternal characteristics or glycemic indices between the MDI and pump groups, except for a longer duration of type 1 diabetes and higher frequencies of microangiopathy and real-time CGM among pump users. Despite improvement with each trimester, glucose levels remained suboptimal throughout pregnancy in both groups. There were no differences between the MDI and pump groups concerning the respective associations with any of the outcomes. The frequency of large for gestational age was high in both groups (MDI 49% vs pump 63%) and did not differ significantly. CONCLUSIONS:
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Authors | Karin Kjölhede, Kerstin Berntorp, Karl Kristensen, Anastasia Katsarou, Nael Shaat, Nana Wiberg, Filip K Knop, Lars Kristensen, Annika Dotevall, Anders Elfvin, Ulrika Sandgren, Verena Sengpiel, Linda Englund-Ögge |
Journal | Acta obstetricia et gynecologica Scandinavica
(Acta Obstet Gynecol Scand)
Vol. 100
Issue 5
Pg. 927-933
(05 2021)
ISSN: 1600-0412 [Electronic] United States |
PMID | 33176006
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | © 2021 Nordic Federation of Societies of Obstetrics and Gynecology. |
Chemical References |
- Blood Glucose
- Hypoglycemic Agents
- Insulin
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Topics |
- Adult
- Blood Glucose
(analysis)
- Blood Glucose Self-Monitoring
(methods)
- Cohort Studies
- Diabetes Mellitus, Type 1
(blood)
- Female
- Glycemic Control
(standards)
- Humans
- Hypoglycemic Agents
(administration & dosage)
- Infant Health
- Infusion Pumps
- Injections, Subcutaneous
- Insulin
(administration & dosage)
- Maternal Health
- Pregnancy
- Pregnancy Outcome
- Pregnancy in Diabetics
(blood)
- Retrospective Studies
- Sweden
(epidemiology)
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