Abstract | BACKGROUND: METHODS: We reviewed the Wake-up Safe database from 2010 to 2017 and identified all reported instances of anaphylaxis. The triggering agent, timing, and location of the registered event, severity of patient harm, and preventability were identified. Narrative review of free-text comments entered by reporting centers was performed to determine presenting symptoms, and interventions required. Type of case was identified from procedure codes provided in mandatory fields. RESULTS: CONCLUSION: The estimated incidence of anaphylaxis and inciting agents among the pediatric population in this study were consistent with the most recent published studies outside of the United States; however, new findings included need for cardiopulmonary resuscitation in 11% of cases, and estimated fatality of 1.6%. The management of perioperative anaphylaxis could be improved for some cases as epinephrine was not administered, or its administration was delayed. Fewer than half of reported cases had additional investigation to formally identify the responsible agent.
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Authors | Mayuko Wakimoto, Rebecca Miller, Stephani S Kim, Joshua C Uffman, Olubukola O NafiuS, Joseph D Tobias, Ralph J Beltran |
Journal | Paediatric anaesthesia
(Paediatr Anaesth)
Vol. 31
Issue 2
Pg. 205-212
(02 2021)
ISSN: 1460-9592 [Electronic] France |
PMID | 33141983
(Publication Type: Journal Article, Review)
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Copyright | © 2020 John Wiley & Sons Ltd. |
Chemical References |
- Anesthetics
- Neuromuscular Blocking Agents
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Topics |
- Adult
- Anaphylaxis
(epidemiology)
- Anesthesia
- Anesthetics
- Child
- Drug Hypersensitivity
(epidemiology)
- Humans
- Neuromuscular Blocking Agents
(adverse effects)
- United States
(epidemiology)
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