Abstract | BACKGROUND AND AIM: The new definition for metabolic associated fatty liver disease (MAFLD), formerly named non-alcoholic fatty liver disease ( NAFLD), would undoubtedly have significant influence on diagnosis, epidemiology, and new drug research. We investigated the prevalence and risk factors of MAFLD among people living with HIV (PLWH). METHODS: In this cross-sectional study, transient elastography was performed in PLWH without significant alcohol intake and hepatitis B virus and hepatitis C virus infection. NAFLD was diagnosed as controlled attenuation parameter (CAP) ≥ 248 dB/m by transient elastography, and MAFLD was defined according to the 2020 international consensus. Advanced fibrosis was defined as liver stiffness measurement (LSM) ≥ 10 kPa. RESULTS: Among the 361 PLWH enrolled, the prevalence of NAFLD and MAFLD were 37.67% and 34.90%, respectively. Compared with the non-MAFLD group, the prevalence of elevated alanine aminotransferase (ALT) level (44.44% vs 16.17%, P < 0.001) and advanced fibrosis (19.05% vs 2.55%, P < 0.001) were significantly higher in the MAFLD group. A positive correlation between LSM and CAP values was found in the MAFLD group (rs = 0.350, P < 0.001) but not in the non-MAFLD group. In multivariate analysis, independent risk predictors for MAFLD were higher ALT level (odds ratio [OR] 1.015, 95% confidence interval [CI] 1.003-1.028, P = 0.018), higher uric acid (OR 1.005, 95% CI 1.002-1.009, P = 0.003), higher total cholesterol (OR 1.406, 95% CI 1.029-1.921, P = 0.032), and greater waist-height ratio (OR 1.291, 95% CI 1.196-1.393, P < 0.001). CONCLUSIONS: A third of PLWH had MAFLD, which was highly accordant with the prevalence of NAFLD. Routine screening for MAFLD is necessary in PLWH.
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Authors | Danping Liu, Yinzhong Shen, Renfang Zhang, Jingna Xun, Jiangrong Wang, Li Liu, Corklin Steinhart, Jun Chen, Hongzhou Lu |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 36
Issue 6
Pg. 1670-1678
(Jun 2021)
ISSN: 1440-1746 [Electronic] Australia |
PMID | 33140878
(Publication Type: Journal Article)
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Copyright | © 2020 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. |
Topics |
- Adult
- China
(epidemiology)
- Cross-Sectional Studies
- Elasticity Imaging Techniques
- Female
- HIV Infections
(complications, epidemiology)
- Humans
- Male
- Mass Screening
- Middle Aged
- Non-alcoholic Fatty Liver Disease
(diagnosis, epidemiology, etiology, prevention & control)
- Prevalence
- Risk Factors
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