Abstract | OBJECTIVE: The effect of patient sex in continuous-flow ventricular assist device (c-VAD) therapy has not been well described. We investigated sex-specific differences in clinical outcomes related to c-VAD therapy for Japanese patients. METHODS: We retrospectively analyzed 153 patients, including 41 (27%) female patients who underwent c-VAD implantation over the last 13 years in our institution for a mean follow-up of 766 ± 446 days. Clinical outcomes were compared between male and female patients RESULTS: There was no significant difference in mortality, cerebral vascular accidents, the severity of heart failure, or driveline infection in patients who underwent c-VAD implantation, regardless of sex. While male patients tended to have more bleeding at the time of surgery, female patients had significantly higher rates of non-surgical bleeding during subsequent c-VAD therapy, mainly from gynecological origins. CONCLUSIONS: Female patients treated with c-VAD had a significantly higher incidence of non-surgical bleeding events. Careful attention to gynecological complications and sex-specific care is required in female patients with c-VAD.
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Authors | Yorihiko Matsumoto, Satsuki Fukushima, Yusuke Shimahara, Naoki Tadokoro, Takashi Kakuta, Junjiro Kobayashi, Tomoyuki Fujita |
Journal | General thoracic and cardiovascular surgery
(Gen Thorac Cardiovasc Surg)
Vol. 69
Issue 6
Pg. 919-925
(Jun 2021)
ISSN: 1863-6713 [Electronic] Japan |
PMID | 33136257
(Publication Type: Journal Article)
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Topics |
- Female
- Heart Failure
(therapy)
- Heart Transplantation
- Heart-Assist Devices
- Humans
- Male
- Retrospective Studies
- Sex Characteristics
- Treatment Outcome
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