Abstract |
Esophageal cancer is the sixth most common cause of cancer-related death worldwide. Peptide modified nanoparticles have been engineered as novel strategies to improve esophageal adenocarcinoma (EAC) therapy. This study aimed to develop a trastuzumab (TAB) modified system for the delivery of cisplatin (CIS) and fluoropyrimidine (5-FU). In the present study, CIS and 5-FU co-encapsulated lipid- polymer hybrid nanoparticles (CIS/5-FU LPHNs) were prepared. TAB was conjugated to the surface of CIS/5-FU LPHNs to achieve TAB decorated CIS/5-FU LPHNs (TAB-CIS/5-FU LPHNs). After the in vitro assessment, a subcutaneous model was used for the in vivo study. The mean diameter of LPNHs was around 100 nm, with higher encapsulation efficacy (EE) of about 90%. The LPNHs was stable and able to release drugs in sustained manners. 63.9% of cell uptake was achieved by TAB-CIS/5-FU LPHNs, with the best in vivo antitumor ability. The best synergistic effect with the lowest CI value (0.68) was achieved at the ratio of 1/1, which was determined for the dosage of drugs in the LPHNs preparation. TAB-CIS/5-FU LPHNs provide a new strategy for synergistic treating of EAC with higher efficacy and reduced side effects, introducing this system as a candidate for EAC therapy.
|
Authors | Qingxia Fu, Jiancheng Wang, Hong Liu |
Journal | Drug delivery
(Drug Deliv)
Vol. 27
Issue 1
Pg. 1535-1543
(Dec 2020)
ISSN: 1521-0464 [Electronic] England |
PMID | 33118428
(Publication Type: Journal Article)
|
Chemical References |
- Antineoplastic Agents
- Lipids
- Polymers
- Trastuzumab
- Cisplatin
- Fluorouracil
|
Topics |
- Adenocarcinoma
(drug therapy)
- Animals
- Antineoplastic Agents
(administration & dosage)
- Cell Line, Tumor
- Cisplatin
(administration & dosage)
- Drug Delivery Systems
(methods)
- Drug Liberation
(drug effects)
- Esophageal Neoplasms
(drug therapy)
- Fluorouracil
(administration & dosage)
- Humans
- Lipids
(administration & dosage)
- Mice, Inbred BALB C
- Mice, Nude
- Nanoparticles
(administration & dosage)
- Particle Size
- Polymers
(administration & dosage)
- Trastuzumab
(administration & dosage)
|