Abstract | BACKGROUND/AIM: The clinical course of acute leukemia is complicated, and it is often necessary to combine or change treatment methods due to the rapid increase and spread of malignant cells. In this study, the potential anti- leukemia activities of prepared garlic essential oil (GEO) and some organosulfur compounds contained therein were examined. MATERIALS AND METHODS: Garlic essential oil component identification by gas chromatography-mass spectrometry (GC-MS). MTT assay evaluated cytotoxicity of tested samples. Leukemia cell differentiation was determined by NBT assay. Apoptosis and related mechanisms were investigated by western blotting. RESULTS: CONCLUSION: The anti- leukemia activity of GEO and organosulfur compound DADS through the action of ROS elevation was herein confirmed.
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Authors | Sze Fat Tin Agassi, Tsung-Ming Yeh, Ching-Dong Chang, Jue-Liang Hsu, Wen-Ling Shih |
Journal | Anticancer research
(Anticancer Res)
Vol. 40
Issue 11
Pg. 6345-6354
(Nov 2020)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 33109572
(Publication Type: Journal Article)
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Copyright | Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. |
Chemical References |
- Oils, Volatile
- Reactive Oxygen Species
- Sulfur Compounds
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Topics |
- Apoptosis
(drug effects)
- Cell Differentiation
(drug effects)
- Garlic
(chemistry)
- HL-60 Cells
- Humans
- Leukemia, Promyelocytic, Acute
(pathology)
- Oils, Volatile
(pharmacology)
- Reactive Oxygen Species
(metabolism)
- Signal Transduction
(drug effects)
- Sulfur Compounds
(pharmacology)
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