NONPERFUSION AREA QUANTIFICATION IN BRANCH RETINAL VEIN OCCLUSION: A Widefield Optical Coherence Tomography Angiography Study.

Abstract

PURPOSE:

To precisely quantify retinal nonperfusion areas (NPAs) in branch retinal vein occlusion using widefield optical coherence tomography angiography (OCTA) and examine their association with neovascular complications.

METHODS:

We enrolled 26 patients with treatment-naïve branch retinal vein occlusion and prospectively examined them for 12 months. After 3 monthly ranibizumab injections to treat macular edema, each patient underwent ultra-widefield (UWF) fluorescein angiography (FA) and OCTA. Ultra-widefield FA was additionally performed at Month 12. For UWF FA, the retinal NPA was measured using the equipment's built-in software. For OCTA, we used panoramic image montaged from 5 single 12 × 12 mm2 images and quantified the retinal NPA using a Gullstrand eye with a grid scale at each patient. Measurements were expressed in terms of actual values and disc area units.

RESULTS:

The retinal NPAs as measured using single OCTA and panoramic OCTA were significantly associated with that measured using UWF FA (P < 0.001 for both). Retinal neovascularization lesions were observed in 4 (15.4%) of 26 eyes. For patients with accompanying neovascularization, the retinal NPA measured using UWF FA, single OCTA, and panoramic OCTA were 187.9 ± 39.5 mm2 (109.9 ± 21.4 disc area), 34.3 ± 13.7 mm2 (19.9 ± 7.7 disc area), and 106.6 ± 24.5 mm2 (62.4 ± 13.6 disc area), respectively, which were larger than for those without neovascularization (P < 0.001, 0.014, and <0.001, respectively).

CONCLUSION:

Using widefield OCTA, we could quantify the retinal NPA of eyes with branch retinal vein occlusion. These could serve as valid references to assess the risk of neovascular complications.

• Authors: Shin Kadomoto, Yuki Muraoka, Akihito Uji, Ryosuke Tamiya, Yasuyuki Oritani, Kentaro Kawai, Sotaro Ooto, Tomoaki Murakami, Yuko Iida-Miwa, Akitaka Tsujikawa
• Journal: Retina (Philadelphia, Pa.) (Retina) Vol. 41 Issue 6 Pg. 1210-1218 (Jun 01 2021) ISSN: 1539-2864 [Electronic] United States
• PMID: 33105300 (Publication Type: Journal Article)

Topics

• Aged
• Female
• Fluorescein Angiography (methods)
• Follow-Up Studies
• Fundus Oculi
• Humans
• Male
• Prospective Studies
• Reproducibility of Results
• Retinal Vein (diagnostic imaging)
• Retinal Vein Occlusion (diagnosis, physiopathology)
• Tomography, Optical Coherence (methods)
• Visual Acuity