Abstract | BACKGROUND: OBJECTIVES: We investigated the association between soy food intake and NAFLD in a Chinese cohort. METHODS: A total of 24,622 participants aged 20-90 y were included in the study. Diet information was collected using a validated 100-item FFQ. NAFLD was defined as having fatty liver diagnosed by ultrasonography and excluding men and women who consumed >210 g alcohol/wk and >140 g/wk, respectively. Logistic regression analysis was used to assess the association of soy food intake with NAFLD. RESULTS: After adjustment for potential confounders, and taking those with <1 time/wk soy food intake as the reference group, the ORs for NAFLD across soy food intake frequency were 0.94 (95% CI: 0.83, 1.07) for 1 time/wk, 0.88 (95% CI: 0.78, 0.99) for 2-3 times/wk, and 0.75 (95% CI: 0.65, 0.87) for ≥4 times/wk (P-trend <0.0001). The results were similar when participants were categorized by the energy-adjusted soy food intake (grams per 1000 kilocalories) quartiles (OR = 0.80; 95% CI: 0.71, 0.91; comparing extreme quartiles). CONCLUSIONS: Higher soy food intake was associated with a lower prevalence of NAFLD in Chinese adults. Further prospective studies and randomized clinical trials are necessary to confirm if soy food intake is inversely related to the risk of NAFLD.
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Authors | Shunming Zhang, Shubham Kumari, Yeqing Gu, Xiaohui Wu, Xiaoyue Li, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Yawen Wang, Tingjing Zhang, Xuena Wang, Xingqi Cao, Huiping Li, Yunyun Liu, Xiaohe Wang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Zhong Sun, Kaijun Niu |
Journal | The Journal of nutrition
(J Nutr)
Vol. 150
Issue 12
Pg. 3280-3287
(12 10 2020)
ISSN: 1541-6100 [Electronic] United States |
PMID | 33097932
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © The Author(s) 2020. Published by Oxford University Press on behalf of the American Society for Nutrition. |
Topics |
- Adult
- Aged
- Aged, 80 and over
- China
(epidemiology)
- Cohort Studies
- Diet
- Female
- Humans
- Male
- Middle Aged
- Non-alcoholic Fatty Liver Disease
(epidemiology, prevention & control)
- Risk Factors
- Soy Foods
- Young Adult
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