Abstract | OBJECTIVE: METHODS: RESULTS: In biopsy specimen, patients with a higher number of CD8+ T cells and FoxP3+ T cells had a better disease-specific survival than patients with a lower number of CD8+ T cells and FoxP3+ cells (P = 0.018 and P = 0.009). Multivariate analysis showed that equivalent dose in 2 Gy fractions (EQD2) of the minimum dose to 90% of the high-risk clinical target volume, FoxP3+ T cells and expression of human leukocyte antigen class I were significant prognostic factors. When the EQD2 is 70 Gy or more, a higher local control rate is obtained regardless of the number of CD8- or FoxP3-positive cells. When EQD2 is <70 Gy, the number of CD8-positive cells has a significant impact on treatment outcome: the recurrence rate (local recurrence rate + distant metastasis rate) was 46.2% in the group with a CD8 value of 230 or higher, whereas the recurrence rate was 75.7% in the group with a CD8 value of less than 230. CONCLUSION: The combination of CD8 or FoxP3 with EQD2 can be potentially useful to predict the treatment results of radiotherapy for cervical cancer, leading to individualized optimal selection of treatment for cervical cancer.
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Authors | Masanori Someya, Takaaki Tsuchiya, Yuki Fukushima, Tomokazu Hasegawa, Yu Takada, Masakazu Hori, Katsutoshi Miura, Mio Kitagawa, Toshio Gocho, Yoshihiko Hirohashi, Toshihiko Torigoe, Masahiro Iwasaki, Motoki Matsuura, Tsuyoshi Saito, Koh-Ichi Sakata |
Journal | Japanese journal of clinical oncology
(Jpn J Clin Oncol)
Vol. 50
Issue 11
Pg. 1290-1297
(Oct 22 2020)
ISSN: 1465-3621 [Electronic] England |
PMID | 33089868
(Publication Type: Journal Article)
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Copyright | © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: [email protected]. |
Chemical References |
- FOXP3 protein, human
- Forkhead Transcription Factors
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Topics |
- Adult
- Aged
- Aged, 80 and over
- CD8-Positive T-Lymphocytes
(immunology)
- Disease-Free Survival
- Female
- Forkhead Transcription Factors
(metabolism)
- Humans
- Lymphocytes, Tumor-Infiltrating
(immunology, metabolism, pathology)
- Middle Aged
- Multivariate Analysis
- Neoplasm Recurrence, Local
(pathology)
- Retrospective Studies
- Treatment Outcome
- Uterine Cervical Neoplasms
(immunology, pathology, radiotherapy)
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