Clinical presentation of a neuropsychiatric lupus patient with symmetrical basal ganglia lesions containing cytotoxic oedema cores surrounded by vasogenic oedema.

Abstract

Neuropsychiatric (NP) manifestations of systemic lupus erythematosus (SLE) are diverse, but involvement of basal ganglia is rare. We describe here a 28-year-old woman with NPSLE presenting aseptic meningitis accompanied by elevated interleukin-6 levels in the cerebrospinal fluid, who developed symmetrical basal ganglia lesions, containing a cytotoxic oedematous core, surrounded by vasogenic oedema upon magnetic resonance imaging. We were able to observe these lesions from a de novo appearance during the disease onset to its disappearance during immunosuppressive treatment. Reversibility upon immunosuppressive treatment indicated that autoimmune mediated mechanisms could contribute to the basal ganglia lesions in NPSLE.

• Authors: Syoko Tsubouchi, Haeru Hayashi, Koichiro Tahara, Kayo Ishii, Takuya Yasuda, Yusuke Yamamoto, Takahiro Mizuuchi, Hiroaki Mori, Mayu Tago, Eri Kato, Tetsuji Sawada
• Journal: Modern rheumatology case reports (Mod Rheumatol Case Rep) Vol. 4 Issue 1 Pg. 39-46 (01 2020) ISSN: 2472-5625 [Electronic] England
• PMID: 33086978 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunosuppressive Agents

Topics

• Adult
• Basal Ganglia (drug effects, pathology)
• Edema (diagnosis, drug therapy, etiology)
• Female
• Humans
• Immunosuppressive Agents (pharmacology, therapeutic use)
• Lupus Erythematosus, Systemic (complications, diagnosis, drug therapy)
• Lupus Vasculitis, Central Nervous System (diagnosis, drug therapy, etiology)
• Symptom Assessment