Sex-Biased Molecular Signature for Overall Survival of Liver Cancer Patients.

Abstract

Sex/gender disparity has been shown in the incidence and prognosis of many types of diseases, probably due to differences in genes, physiological conditions such as hormones, and lifestyle between the sexes. The mortality and survival rates of many cancers, especially liver cancer, differ between men and women. Due to the pronounced sex/gender disparity, considering sex/ gender may be necessary for the diagnosis and treatment of liver cancer. By analyzing research articles through a PubMed literature search, the present review identified 12 genes which showed practical relevance to cancer and sex disparities. Among the 12 sex-specific genes, 7 genes (BAP1, CTNNB1, FOXA1, GSTO1, GSTP1, IL6, and SRPK1) showed sex-biased function in liver cancer. Here we summarized previous findings of cancer molecular signature including our own analysis, and showed that sexbiased molecular signature CTNNB1High, IL6High, RHOAHigh and GLIPR1Low may serve as a female-specific index for prediction and evaluation of OS in liver cancer patients. This review suggests a potential implication of sex-biased molecular signature in liver cancer, providing a useful information on diagnosis and prediction of disease progression based on gender.

• Authors: Sun Young Kim, Hye Kyung Song, Suk Kyeong Lee, Sang Geon Kim, Hyun Goo Woo, Jieun Yang, Hyun-Jin Noh, You-Sun Kim, Aree Moon
• Journal: Biomolecules & therapeutics (Biomol Ther (Seoul)) Vol. 28 Issue 6 Pg. 491-502 (Nov 01 2020) ISSN: 1976-9148 [Print] Korea (South)
• PMID: 33077700 (Publication Type: Journal Article, Review)