Expanding Patch Testing Beyond the Baseline Series: Usefulness of Customized Antimicrobials, Vehicles, and Cosmetics Series.

Abstract

BACKGROUND:

Testing cosmetics and their ingredients is essential to avoid missing relevant allergens and to monitor fluctuating incidence of hypersensitivity.

OBJECTIVE:

The aim of this study was to review the usefulness of patch testing with a customized antimicrobials, vehicles, and cosmetics (AVC) series over 15 years at a single Canadian site.

METHODS:

Between January 1, 2005, and December 31, 2019, patients suspected of having cosmetics allergy were patch tested with a 40-allergen AVC series in addition to the North American Contact Dermatitis Group standard screening series. We reviewed the patch test results of 2868 patients.

RESULTS:

We consecutively patch tested with the baseline series 6103 patients, of which 2868 (47%) were also tested with the AVC series. Of 53 different allergens that were tested at some point, 26 remained in the series throughout the 15-year span. The most common positive allergens were thimerosal (4.52%), polyvidone-iodine (2.25%), propolis (2.06%), sodium metabisulfite (1.94%), dodecyl gallate (1.53%), carmine (1.10%), lauryl glucoside (1.01%), sandalwood oil (0.7%), and tert-butylhydroquinone (0.7%).

CONCLUSIONS:

Although the expansion of the North American Contact Dermatitis Group standard screening series has decreased the yield from the AVC series from 21.1% to 13.9%, it still remains a useful adjunct for patients suspected of having cosmetics or disinfectants allergy.

• Authors: Catherine Besner Morin, Denis Sasseville
• Journal: Dermatitis : contact, atopic, occupational, drug (Dermatitis) 2020 Nov/Dec Vol. 31 Issue 6 Pg. 367-372 ISSN: 2162-5220 [Electronic] United States
• PMID: 33074937 (Publication Type: Journal Article)

Chemical References

• Anti-Infective Agents
• Cosmetics
• Glucosides
• Hydroquinones
• Pharmaceutical Vehicles
• Plant Oils
• Sesquiterpenes
• Sulfites
• Thimerosal
• lauryl gallate
• sodium metabisulfite
• dodecyl glucoside
• Gallic Acid
• Povidone-Iodine
• Propolis
• 2-tert-butylhydroquinone
• Carmine
• sandalwood oil

Topics

• Anti-Infective Agents (adverse effects)
• Canada
• Carmine (adverse effects)
• Cosmetics (adverse effects)
• Dermatitis, Allergic Contact (diagnosis, etiology)
• Gallic Acid (adverse effects, analogs & derivatives)
• Glucosides (adverse effects)
• Humans
• Hydroquinones (adverse effects)
• Patch Tests (methods)
• Pharmaceutical Vehicles (adverse effects)
• Plant Oils (adverse effects)
• Povidone-Iodine (adverse effects)
• Propolis (adverse effects)
• Sesquiterpenes (adverse effects)
• Sulfites (adverse effects)
• Thimerosal (adverse effects)