Chlorogenic Acid Improves Symptoms of Inflammatory Bowel Disease in Interleukin-10 Knockout Mice.

Abstract

Inflammatory bowel disease (IBD) is a chronic intestinal inflammation that is highly prevalent worldwide. Interleukin (IL)-10 can effectively inhibit negative cascades such as the production of inflammatory mediators (inducible nitric oxide synthase [iNOS], cyclooxygenase-2), accumulation of inflammatory infiltrates (macrophages, eosinophils, neutrophils), toxicity (lower T cell subsets), and secretion of pro-inflammatory cytokines (IL-1β, TNF-α) in tissues such as the spleen, mesenteric lymph nodes (MLN), Peyer's patch (PP), and colon. In this study, we investigated whether chlorogenic acid (CHA) can regulate inflammation in IL-10 knockout (KO) mice used as an IBD animal model. CHA significantly increased the ratio of CD4+/CD8+, T cell subsets in PP, and MLN of IL-10 KO mice. In addition, CHA also morphologically attenuated colon inflammation in IL-10 KO mice. We demonstrated that CHA significantly reduced the expression levels of iNOS, IL-1β, TNF-α, which were highly expressed in IL-10 KO mice. Therefore, CHA may provide beneficial effects for improving IBD by decreasing inflammations.

• Authors: Young Min Lee, Dong Wook Shin, Beong Ou Lim
• Journal: Journal of medicinal food (J Med Food) Vol. 23 Issue 10 Pg. 1043-1053 (Oct 2020) ISSN: 1557-7600 [Electronic] United States
• PMID: 33054539 (Publication Type: Journal Article)

Chemical References

• Cytokines
• Interleukin-10
• Chlorogenic Acid

Topics

• Animals
• Chlorogenic Acid (pharmacology)
• Colitis (drug therapy, genetics)
• Cytokines
• Inflammatory Bowel Diseases (drug therapy, genetics)
• Interleukin-10 (genetics)
• Mice
• Mice, Knockout
• T-Lymphocyte Subsets (cytology)