Abstract | PURPOSE: METHODS: In this randomized, double-blind, placebo-controlled study, 77 healthy adult overweight/obese subjects (aged 56 ± 10 years and BMI 29.0 ± 2.7 kg/m2) with total cholesterol levels of 5.0-8.0 mmol/L (5.9 ± 0.7 mmol/L) were randomly assigned to receive 500 mg of OLE (n = 39) or placebo (n = 38) for 8 weeks. In total, 74 subjects completed the entire study protocol. At baseline, after 4 weeks, and after 8 weeks of supplementation, blood lipid profiles, oxidized low-density lipoprotein ( oxLDL), blood pressure, glucose, and insulin levels were assessed. In addition, liver function parameters were measured at baseline and after 8 weeks. RESULTS: OLE supplementation did not significantly affect blood lipid levels after 4 weeks or after 8 weeks compared to placebo (all p > 0.05). For oxLDL, blood pressure, glucose, and insulin levels and liver function parameters, also no statistically significant differences were found between the two intervention groups (all p > 0.05). CONCLUSIONS: TRIAL REGISTERED: The trial has been registered at ClinicalTrials.gov (NCT02990637).
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Authors | Yala Stevens, Bjorn Winkens, Daisy Jonkers, Adrian Masclee |
Journal | European journal of nutrition
(Eur J Nutr)
Vol. 60
Issue 4
Pg. 2111-2120
(Jun 2021)
ISSN: 1436-6215 [Electronic] Germany |
PMID | 33034707
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Biomarkers
- Plant Extracts
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Topics |
- Adult
- Biomarkers
- Dietary Supplements
- Double-Blind Method
- Humans
- Obesity
(drug therapy)
- Olea
- Overweight
(drug therapy)
- Plant Extracts
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