Prostate cancer is one of the major
cancers of the genitourinary tract. High-mobility group box 1 (
HMGB1) was suggested as a promising therapeutic target for
prostate cancer. In this study, we aim to elucidate the associations of
HMGB1 single nucleotide polymorphisms (SNPs) with
prostate cancer susceptibility and clinicopathological characteristics. The
HMGB1 SNPs rs1412125, rs2249825, rs1045411, and rs1360485 in 579
prostate cancer patients and 579
cancer-free controls were analyzed with real-time polymerase chain reactions (real-time PCR). All of the data were evaluated with SAS statistical software. Our results showed that the
HMGB1 rs1045411 T allele genotype was significantly associated with advanced pathologic T stage (odds ratio (OR) = 1.433, 95% confidence interval (CI) = 1.021‒2.012; p = 0.037) and pathologic N1 stage (OR = 2.091, 95% CI = 1.160‒3.767; p = 0.012), and the rs1360485 polymorphic CT + TT genotype was associated with pathologic Gleason grade group (4 + 5) (OR = 1.583, 95% CI = 1.017‒2.462; p = 0.041), pathologic T stage (3 + 4) (OR = 1.482, 95% CI = 1.061‒2.070; p = 0.021), and pathologic N1 stage (OR = 2.131, 95% CI = 1.178‒3.852; p = 0.011) compared with their wild-type carriers. In conclusion, our results revealed that the
HMGB1 SNPs were associated with the clinical status of
prostate cancer. The
HMGB1 SNPs may have the potential to predict
prostate cancer disease progression.