A Dinuclear Persulfide-Bridged Ruthenium Compound is a Hypoxia-Selective Hydrogen Sulfide (H2 S) Donor.

Abstract

Hydrogen sulfide (H2 S) is a gaseous molecule that has received attention for its role in biological processes and therapeutic potential in diseases, such as ischemic reperfusion injury. Despite its clinical relevance, delivery of H2 S to biological systems is hampered by its toxicity at high concentrations. Herein, we report the first metal-based H2 S donor that delivers this gas selectively to hypoxic cells. We further show that H2 S release from this compound protects H9c2 rat cardiomyoblasts from an in vitro model of ischemic reperfusion injury. These results validate the utility of redox-activated metal complexes as hypoxia-selective H2 S-releasing agents for use as tools to study the role of this gaseous molecule in complex biological systems.

• Authors: Joshua J Woods, Justin J Wilson
• Journal: Angewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl) Vol. 60 Issue 3 Pg. 1588-1592 (01 18 2021) ISSN: 1521-3773 [Electronic] Germany
• PMID: 33022823 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: © 2020 Wiley-VCH GmbH.

Chemical References

• Coordination Complexes
• Sulfides
• persulfides
• Ruthenium
• Hydrogen Sulfide

Topics

• Animals
• Coordination Complexes (chemistry)
• Hydrogen Sulfide (chemistry)
• Hypoxia (metabolism)
• Oxidation-Reduction
• Rats
• Ruthenium (chemistry)
• Sulfides (chemistry)