Metabolic changes are a major feature of
tumors, including various metabolic forms, such as energy,
lipid, and
amino acid metabolism.
Sterol regulatory element binding proteins (SREBPs) are important modules in regulating lipid metabolism and play an essential role in
metabolic diseases. In the previous decades, the regulatory range of SREBPs has been markedly expanded. It was found that SREBPs also played a critical role in
tumor development. SREBPs are involved in energy supply,
lipid supply, immune environment and inflammatory environment shaping in
tumor cells, and as a protective umbrella to support the malignant proliferation of
tumor cells. Natural medicine and
traditional Chinese medicine, as an important part of
drug therapy, demonstrates the multifaceted effects of SREBPs regulation. This review summarizes the core processes in the involvement of SREBPs in
tumors and provides a comprehensive understanding of the pathways through which natural drugs target the SREBP pathway and regulate
tumor progression.