Abstract | BACKGROUND: METHODS: RESULTS: Twenty-one studies incorporating 1,131 patients (272 undergoing total parathyroidectomy, 510 subtotal parathyroidectomy, and 349 less than subtotal parathyroidectomy) were identified. Pooled results revealed increased risk for long-term hypoparathyroidism in total parathyroidectomy patients (relative risk 1.61; 95% confidence interval, 1.12-2.31; P = .009) versus those undergoing subtotal parathyroidectomy. In the less than subtotal parathyroidectomy or subtotal parathyroidectomy comparison group, a greater risk for recurrence of hyperparathyroidism (relative risk 1.37; 95% confidence interval, 1.05-1.79; P = .02), persistence of hyperparathyroidism (relative risk 2.26; 95% confidence interval, 1.49-3.41; P = .0001), and reoperation for hyperparathyroidism (relative risk 2.48; 95% confidence interval, 1.65-3.73; P < .0001) was noted for less than subtotal parathyroidectomy patients, albeit with lesser risk for long-term for hypoparathyroidism (relative risk 0.47; 95% confidence interval, 0.29-0.75; P = .002). CONCLUSION:
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Authors | Constantinos Nastos, Dimitrios Papaconstantinou, Efstratios Kofopoulos-Lymperis, Melpomeni Peppa, Andreas Pikoulis, Panagis Lykoudis, Fausto Palazzo, Paul Patapis, Emmanouil Pikoulis |
Journal | Surgery
(Surgery)
Vol. 169
Issue 2
Pg. 302-310
(02 2021)
ISSN: 1532-7361 [Electronic] United States |
PMID | 33008613
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Copyright | Copyright © 2020 Elsevier Inc. All rights reserved. |
Topics |
- Humans
- Hyperparathyroidism, Primary
(genetics, pathology, surgery)
- Hypoparathyroidism
(epidemiology, etiology, prevention & control)
- Multiple Endocrine Neoplasia Type 1
(complications, genetics, surgery)
- Parathyroid Glands
(pathology, surgery)
- Parathyroidectomy
(adverse effects, methods, statistics & numerical data)
- Postoperative Complications
(epidemiology, etiology, prevention & control)
- Recurrence
- Reoperation
(statistics & numerical data)
- Treatment Outcome
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