Bismuth-Based Mesoporous Nanoball Carrying Sorafenib for Computed Tomography Imaging and Synergetic Chemoradiotherapy of Hepatocellular Carcinoma.

Abstract

Sorafenib (SOR), a multi-kinase inhibitor for advanced hepatocellular carcinoma (HCC), reveals a limited therapeutic effect due to a lack of selectivity and evident drug resistance. In the present study, bismuth-based mesoporous nanomaterial (NBOF) is loaded with SOR and then coated with polyethylene glycol and folic acid conjugates (P-FA) to form an NBOF@SOR-P-FA nanocarrier system. The system achieves significantly enhanced anti-cancer efficacy by combining chemotherapy with radiotherapy. To evaluate the effect of synergistic treatment, cytotoxicity detection, Live/Dead staining, apoptotic assay, and Western blot analysis are performed. The results suggest that NBOF@SOR-P-FA significantly inhibits HCC cell proliferation and promotes cell apoptosis. Also, the NBOF@SOR-P-FA exhibits excellent biocompatibility by hemolysis and serum biochemical tests and produces a substantially enhanced contrast efficiency as compared to iohexol by computed tomography imaging. More importantly, the profound suppression of tumor growth and potentiation of apoptosis are observed in a mouse subcutaneous tumor model. Collectively, these results indicate that the bismuth-based nanotheranostic platform could enhance the therapeutic effect of sorafenib and serve as an innovative method for HCC treatment.

• Authors: Guang-Cong Zhang, Jie Liu, Xiang-Nan Yu, Yong Deng, Yun Sun, Tao-Tao Liu, Ling Dong, Chang-Feng Zhu, Xi-Zhong Shen, Ji-Min Zhu, Shu-Qiang Weng, Yuhao Li
• Journal: Advanced healthcare materials (Adv Healthc Mater) Vol. 9 Issue 21 Pg. e2000650 (11 2020) ISSN: 2192-2659 [Electronic] Germany
• PMID: 33000919 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2020 Wiley-VCH GmbH.

Chemical References

• Antineoplastic Agents
• Niacinamide
• Sorafenib
• Bismuth

Topics

• Animals
• Antineoplastic Agents (pharmacology, therapeutic use)
• Apoptosis
• Bismuth (pharmacology)
• Carcinoma, Hepatocellular (diagnostic imaging, drug therapy)
• Cell Line, Tumor
• Cell Proliferation
• Chemoradiotherapy
• Liver Neoplasms (diagnostic imaging, drug therapy)
• Mice
• Niacinamide
• Sorafenib (pharmacology, therapeutic use)