Intravitreal Voriconazole for Treatment of Bilateral Endogenous Candida Chorioretinitis.

Abstract

This report describes a patient with bilateral endogenous candida chorioretinitis. The patient had a 2-day history of bilateral blurred vision. Fundus photography revealed multiple chorioretinal infiltrations in both eyes and a parafoveal hemorrhage in the left eye. After 2 days, fundus examination showed an increased number of infiltrations and hemorrhages in both eyes and worsening vitreous inflammation. A large infiltrative intraretinal lesion and a retinal hemorrhage of the left eye were discovered on optical coherence tomography. Candida albicans was diagnosed from blood culture. The bilateral candida chorioretinitis had not responded to systemic or topical antifungal medication. The chorioretinitis was refractory to intravitreal amphotericin B as well. Intravitreal voriconazole injection in both eyes and intravitreal bevacizumab injection in the left eye were performed thereafter. The chorioretinal infiltrations and hemorrhages decreased in both eyes. Intravitreal voriconazole injection was effective in the treatment of intractable candida chorioretinitis.

• Authors: Ha Eun Sim, Min Ji Kang, Jae Suk Kim, Je Hyung Hwang
• Journal: Case reports in ophthalmology (Case Rep Ophthalmol) 2020 May-Aug Vol. 11 Issue 2 Pg. 402-410 ISSN: 1663-2699 [Print] Switzerland
• PMID: 32999668 (Publication Type: Case Reports)
• Copyright: Copyright © 2020 by S. Karger AG, Basel.