Risk factors for subclinical renal damage and its progression: Hanzhong Adolescent Hypertension Study.

Abstract

BACKGROUND/OBJECTIVES:

Chronic kidney disease (CKD) is a global public health problem, including in China. The aim of this study was to identify the risk factors for the development and progression of subclinical renal disease (SRD) in a Chinese population. We also examined whether the impact of the risk factors on SRD changed over time.

SUBJECTS/METHODS:

To identify the predictors of SRD, we performed a cross-sectional study of the 2432 subjects in our Hanzhong Adolescent Hypertension Cohort. A subgroup of 202 subjects was further analyzed over a 12-year period from 2005 to 2017 to determine the risk factors for the development and progression of SRD.

RESULTS:

In cross-sectional analysis, elevated blood pressure, male gender, diabetes, body mass index, and triglyceride were independently associated with a higher risk of SRD. In longitudinal analysis, an increase in total cholesterol over a 4-year period and an increase in serum triglyceride over a 12-year period were independently associated with progression of albuminuria. Finally, increases in both total cholesterol and serum uric acid over a 4-year follow-up showed an independent association with a modest reduction in estimated glomerular filtration rate (eGFR).

CONCLUSIONS:

In this study of a Chinese cohort, we show several metabolic abnormalities as independent risk factors for subclinical renal disease in a Chinese cohort. In addition, we demonstrate that the effects of total cholesterol, triglycerides and uric acid on the development and progression of albuminuria or the decline in eGFR vary at different points of follow-up. These findings highlight the importance of early detection of metabolic abnormalities to prevent SRD.

• Authors: Yang Wang, Ming-Fei Du, Wei-Hua Gao, Bo-Wen Fu, Qiong Ma, Yu Yan, Yue Yuan, Chao Chu, Chen Chen, Yue-Yuan Liao, Ke Gao, Ke-Ke Wang, Min Li, Yue Sun, Jia-Wen Hu, Xin Chen, Qiong Ma, Dan Wang, Xiao-Yu Zhang, Chun-Hua Li, Hao-Wei Zhou, Wan-Hong Lu, Zu-Yi Yuan, John Chang, Jian-Jun Mu
• Journal: European journal of clinical nutrition (Eur J Clin Nutr) Vol. 75 Issue 3 Pg. 531-538 (03 2021) ISSN: 1476-5640 [Electronic] England
• PMID: 32994554 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Uric Acid

Topics

• Adolescent
• China (epidemiology)
• Cross-Sectional Studies
• Disease Progression
• Glomerular Filtration Rate
• Humans
• Hypertension (epidemiology, etiology)
• Male
• Renal Insufficiency, Chronic (epidemiology, etiology)
• Risk Factors
• Uric Acid