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In situ decorated Au NPs on pectin-modified Fe3O4 NPs as a novel magnetic nanocomposite (Fe3O4/Pectin/Au) for catalytic reduction of nitroarenes and investigation of its anti-human lung cancer activities.

Abstract
In recent days, the green synthesized nanomagnetic biocomposites have been evolved with tremendous potential as the future catalysts. This has encouraged us to design and synthesis of a novel Au NPs immobilized pectin modified magnetic nanoparticles (Fe3O4/Pectin/Au). It was meticulously characterized using advanced analytical techniques like FT-IR, FESEM, TEM, EDX, XPS, VSM, XRD and ICP-OES. We investigated the chemical applications of the material in the catalytic reduction of nitroarenes using N2H4.H2O as the reducing agent in the EtOH/H2O solvent without any promoters or ligands. Due to strong paramagnetism, the catalyst was easily recovered and reused in 11 cycles without considerable leaching or loss in reactivity. The green protocol involves several advantages like mild conditions, easy workup, high yields, and reusability of the catalyst. Furthermore, the desired nanocomposite was employed in biological studies like anti-oxidant assay by DPPH radical scavenging test. Subsequently, on exhibiting a good IC50 value in the DPPH assay, we extended the bio-application of the Fe3O4/Pectin/Au in the anticancer study of adenocarcinoma cells of human lungs using three cancer cell lines, PC-14, LC-2/ad and HLC-1 and a normal cell line HUVEC. The best result was accomplished in PC-14 cell lines with the lowest IC50 values.
AuthorsYun Li, Na Li, Wei Jiang, Guoyuan Ma, Mohammad Mahdi Zangeneh
JournalInternational journal of biological macromolecules (Int J Biol Macromol) Vol. 163 Pg. 2162-2171 (Nov 15 2020) ISSN: 1879-0003 [Electronic] Netherlands
PMID32961190 (Publication Type: Journal Article)
CopyrightCopyright © 2020 Elsevier B.V. All rights reserved.
Chemical References
  • Ferric Compounds
  • Magnetite Nanoparticles
  • ferric oxide
  • Gold
  • Pectins
Topics
  • Catalysis
  • Cell Line, Tumor
  • Ferric Compounds (chemistry, pharmacology)
  • Gold (chemistry, pharmacology)
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Lung Neoplasms (drug therapy)
  • Magnetite Nanoparticles (chemistry, therapeutic use)
  • Nanocomposites (chemistry, therapeutic use)
  • Pectins (chemistry, pharmacology)
  • Spectroscopy, Fourier Transform Infrared

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