Pectins

High molecular weight polysaccharides present in the cell walls of all plants. Pectins cement cell walls together. They are used as emulsifiers and stabilizers in the food industry. They have been tried for a variety of therapeutic uses including as antidiarrheals, where they are now generally considered ineffective, and in the treatment of hypercholesterolemia.

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Networked: 902 relevant articles (72 outcomes, 162 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	de Vos, Paul: 9 articles (10/2021 - 01/2017)
2.	Chapkin, Robert S: 8 articles (01/2018 - 11/2002)
3.	Zhou, Yifa: 7 articles (01/2021 - 02/2013)
4.	Schols, Henk A: 6 articles (01/2022 - 07/2010)
5.	Ding, Kan: 6 articles (09/2021 - 07/2016)
6.	Tai, Guihua: 6 articles (01/2021 - 02/2013)
7.	Lionetti, Vincenzo: 6 articles (09/2018 - 04/2011)
8.	Perelman, Michael: 6 articles (01/2016 - 05/2013)
9.	Beukema, Martin: 5 articles (10/2021 - 01/2018)
10.	Driouich, Azeddine: 5 articles (01/2021 - 10/2005)

Related Diseases

1.	Colitis 04/30/2020 - "Specifically, compared to high esterified pectin, low esterified pectin displayed better protective effects in acute colitis mice." 10/12/2023 - "In this study, we aimed to investigate whether dietary pectin alleviates Salmonella typhimurium-induced colitis in mice. " 05/22/2023 - "Our previous study has shown that pectin with various degrees of esterification displayed different effects on preventing acute colitis and regulating the gut microbiome and serum metabolome. " 05/01/2022 - "This study aimed to clarify the underlying correlations of gut microbiome and serum metabolites with the preventive effects of pectin with different esterification degrees (H121, L13, and L102) against colitis in mice. " 10/12/2023 - "Collectively, pectin ameliorated Salmonella typhimurium-induced colitis, oxidative stress, and tight junction, which may be related to the inactivation of TLR2-NF-κB signalling and reduced abundance of Salmonella."
2.	Infections 01/01/2003 - "It was shown that in the group of the patients treated with pectins vs the control group development of pyo-inflammatory infections was less frequent, the indices of the immunity status improved and a more rapid decrease of the intoxication and a more rapid normalization of the composition of various biotopes in the patients were observed." 11/01/2021 - "Furthermore, at the end of the 56 days of feeding trial, shrimp receiving CPH pectin and/or LP treatments showed a significantly higher survival ratio against V. alginolyticus infection and hypothermal stress. " 08/01/1994 - "[Experimental and clinical studies of the effect of pectin on the causative agents of acute intestinal infections]." 03/01/1950 - "Studies of rabbit organs after intravenous infections of pectin sols." 09/29/2023 - "maydis infection altered methyl esterification of pectin, and the degree of methyl esterification was correlated with the resistance of maize to U. "
3.	Colonic Neoplasms (Colon Cancer) 01/01/2021 - "Collectively, our findings indicate that DHCP has a favorable toxicity profile and is a new TRAIL sensitizer that shows promise in the development of pectin-based pharmaceuticals, nutraceuticals, and dietary agents aimed at combating human colon cancer." 01/01/2003 - "Dietary pectins and their degradation products may contribute to the reported protective effects of fruits against colon cancer." 11/14/2022 - "The data compilation described herein can guide future clinical trials to investigate how to target specific pectin structures to act as an adjuvant in colon cancer treatment." 11/05/2015 - "In this study several pectin extracts representing different structural components of pectin were assessed for effects against colon cancer cells. " 02/01/2013 - "In this study, we investigated the effects of four structurally distinct pectins on human colon cancer HT-29 cells and the possible mechanisms accounting for the actions. "
4.	Body Weight (Weight, Body) 02/01/1995 - "Pectin significantly decreased (P < 0.05) body weight loss, increased (P < 0.05) stool solidity, and improved (P = 0.05) colonic water absorption following resection without significantly altering mucosal structure. " 01/01/2009 - "The body weight of the pectin group was lower (p < 0.05) during the study's second and third weeks (192.42 +/- 16.67 and 228.75 +/- 19.81 g, respectively, and 202.87 +/- 19.96 and 243.51 +/- 20.44 g for the control group). " 02/01/1985 - "By the end of the study body weights were significantly lower in the 6 and 8% pectin groups after adjusting for their nonsignificant trend of lower food intake. " 06/01/2016 - "Results Our results revealed that pectin feeding led to significant decreases in body weight, energy intake and fat pad weight in rats fed with the standard as well as high-fat diet. " 01/01/2015 - "In both 8- and 28-day cohorts, dietary pectin inclusion rate was negatively correlated with food intake, body weight gain and the change in body fat mass, with no effect on lean mass gain. "
5.	Constipation 12/30/2014 - "For this randomized controlled trial, we evaluated the efficacy of pectin on intestinal transit time and other indices of constipation in adults with slow-transit constipation. " 09/01/2022 - "The findings of this study indicate that OPPE possesses an important role in the gastrointestinal motility regulation, and thus lend pharmacological credence to the suggested use of the natural pectin for the treatment, management, and/or control of constipation." 07/01/2019 - "Structural characterization and rheological properties of a pectin with anti-constipation activity from the roots of Arctium lappa L." 09/01/1987 - "Water-soluble fibers, such as pectin and gums, have little effect on stool weight and hence are not appropriate treatment for patients with constipation. " 12/30/2014 - "To explore the effect of pectin, a kind of soluble dietary fiber, on colonic transit time (CTT), clinical symptoms and gut microbiota in adults with slow-transit constipation. "

Related Drugs and Biologics

1.	Dietary Fiber
2.	Enzymes
3.	Proteins (Proteins, Gene)
4.	Antioxidants
5.	Polyphenols
6.	Fentanyl (Sublimaze)
7.	Nasal Sprays
8.	guar gum (guaran)
9.	Alginates
10.	Acids

Related Therapies and Procedures

1.	Therapeutics
2.	Microspheres (Microsphere)
3.	Fecal Microbiota Transplantation
4.	Oral Administration
5.	Enterosorption