Malignant melanoma arising in a primary mediastinal germ cell tumor.

Abstract

Primary mediastinal germ cell tumors with somatic malignancies are rare. We report a case of a 34-year old man with melanoma arising in a primary mediastinal mixed germ cell tumor. On initial biopsy, the patient was found to have a germ cell tumor containing yolk sac and embryonal components only. After chemotherapy, histopathological evaluation of the residual tumor in the wide local resection specimen revealed a mature teratoma with melanoma. Molecular studies demonstrated that the residual germ cell tumor harbored KIT and NRAS mutations associated with malignant melanoma.

• Authors: Sherry Lee, Yevgen Chornenkyy, Michael T Swete, Samuel S Kim, Ankit Bharat, Ximing J Yang, Anjana Yeldandi
• Journal: Pathology, research and practice (Pathol Res Pract) Vol. 216 Issue 11 Pg. 153210 (Nov 2020) ISSN: 1618-0631 [Electronic] Germany
• PMID: 32950894 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2020 Elsevier GmbH. All rights reserved.

Topics

• Adult
• Humans
• Male
• Mediastinal Neoplasms (pathology)
• Melanoma (pathology)
• Neoplasms, Second Primary (pathology)
• Teratoma (pathology)