Abstract | BACKGROUND: METHODS: In a randomized, double-blind, placebo-controlled trial, 372 patients with NSTE-ACS were randomly assigned to receive STS (n = 192) or saline (n = 180) for 2 days before and 3 days after PCI along with standard therapy. The primary endpoint was the composite incidence of major adverse cardiac events (MACEs), including death, non-fatal myocardial infarction, repeated revascularization of the target vessel, and stent thrombosis, within 30 days after PCI. RESULTS: The 30-day MACEs occurred in 18.8% of the patients in the STS group and in 27.2% of the patients in the control group (P = 0.038); this difference was mostly driven by reduction of myocardial infarction incidence (17.2% vs. 26.7%, P = 0.027). Post-procedural elevation of troponin-I was also significantly lower in the STS group (26.56% vs. 47.78%, P < 0.001). Multivariable analysis identified STS as a predictor of decreased risk of MACE occurrence (odds ratio: 0.60, 95% confidence interval: 0.36 to 0.99; P = 0.045). CONCLUSION: Addition of STS to the standard treatments recommended by the current practice guidelines in patients with NSTE-ACS undergoing PCI could reduce myocardial injury and the occurrence of short-term cardiovascular events, primarily driven by non-fatal myocardial infarction. TRIAL REGISTRATION: ChiCTR-TRC-14005182.
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Authors | Shuai Mao, Lei Wang, Xujie Zhao, Liheng Guo, Qian Lin, Xiaofeng Wang, Xiaohua Dai, Hongcai Shang, Minzhou Zhang, Aleksander Hinek |
Journal | Cardiovascular drugs and therapy
(Cardiovasc Drugs Ther)
Vol. 35
Issue 2
Pg. 321-329
(04 2021)
ISSN: 1573-7241 [Electronic] United States |
PMID | 32940893
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Cardiovascular Agents
- Phenanthrenes
- tanshinone II A sodium sulfonate
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Topics |
- Acute Coronary Syndrome
(classification, mortality, surgery)
- Aged
- Cardiovascular Agents
(adverse effects, therapeutic use)
- Cardiovascular Diseases
(epidemiology)
- Comorbidity
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Percutaneous Coronary Intervention
(methods)
- Phenanthrenes
(adverse effects, therapeutic use)
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