Abstract | BACKGROUND: TRIAL DESIGN: a prospective, randomized, controlled study. METHODS: A total of 210 patients receiving elective operative hysteroscopy from December 2018 to April 2019 were enrolled in the present study. They were randomly equally separated into dezocine group (n = 105) and control group (n = 105). Patients were intravenously pre-administrated with dezocine 0.03 mg/kg (diluted to 5 mL) or the same volume of normal saline 1 min prior to remifentanil infusion. One minute later, intravenous injection of propofol 1.5 mg/kg and cisatracurium 0.1 mg/kg were given to all patients for induction of general anesthesia. The counts of coughs occurred during the anesthesia induction period were recorded and the severity of cough was scaled. RESULTS: There were 7 cases of mild cough in dezocine group and 18 cases of mild cough, 12 cases of moderate cough and 4 cases of severe cough in control group. The incidence rate of cough was significantly lower and the severity of cough was obviously relieved in dezocine group compared to control group (6.67% vs. 32.38%, P < 0.001). The two groups were not significantly different in heart rate and mean arterial pressure before the induction, before and after the intubation, and in operating time and postoperative visual analog scale pain scores. CONCLUSION: TRIAL REGISTRATION: ChiCTR2000032035 . Date of registration: Retrospectively registered on 2020/04/18.
|
Authors | Rui Ma, Yu Wei, Zifeng Xu |
Journal | BMC anesthesiology
(BMC Anesthesiol)
Vol. 20
Issue 1
Pg. 235
(09 16 2020)
ISSN: 1471-2253 [Electronic] England |
PMID | 32938386
(Publication Type: Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Analgesics, Opioid
- Bridged Bicyclo Compounds, Heterocyclic
- Tetrahydronaphthalenes
- Remifentanil
- dezocine
|
Topics |
- Adult
- Aged
- Analgesics, Opioid
(administration & dosage, adverse effects, therapeutic use)
- Anesthesia, General
- Bridged Bicyclo Compounds, Heterocyclic
(administration & dosage, therapeutic use)
- Cough
(chemically induced, prevention & control)
- Female
- Humans
- Hysteroscopy
- Middle Aged
- Prospective Studies
- Remifentanil
(administration & dosage, adverse effects)
- Tetrahydronaphthalenes
(administration & dosage, therapeutic use)
- Treatment Outcome
- Young Adult
|