Quinolizidine alkaloids from the roots of Sophora flavescens.

Abstract

Seventeen quinolizidine alkaloids, including a new matrine-type one, sophcence A (1), were isolated from the roots of Sophora flavescens Alt. The structure of compound 1 was elucidated by means of 1D and 2D NMR, as well as HR-ESI-MS spectroscopic data. The NMR data of (-)-Δ7-dehydrosophoramine (10) and oxy-N-methylcytisine (12) were reported for the first time. In addition, (+)-sophoranol (4) exhibited moderate inhibition on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages with IC50 value of 22.14 μM, while lupanine (17) was found to inhibit the growth of human glioma stem cells GSC-3# at 20 μg/mL.

• Authors: Jian-Chun Li, Zhi-Jun Zhang, Dan Liu, Ming-Yan Jiang, Rong-Tao Li, Hong-Mei Li
• Journal: Natural product research (Nat Prod Res) Vol. 36 Issue 7 Pg. 1781-1788 (Apr 2022) ISSN: 1478-6427 [Electronic] England
• PMID: 32924588 (Publication Type: Journal Article)

Chemical References

• Alkaloids
• Lipopolysaccharides
• Quinolizidines
• Quinolizines

Topics

• Alkaloids (chemistry)
• Humans
• Lipopolysaccharides (pharmacology)
• Plant Roots (chemistry)
• Quinolizidines (pharmacology)
• Quinolizines (chemistry)
• Sophora (chemistry)