Abstract | OBJECTIVE: Increasing evidence indicates that intestinal microbiota play a role in diverse metabolic processes via intestinal butyrate production. Human bariatric surgery data suggest that the gut-brain axis is also involved in this process, but the underlying mechanisms remain unknown. METHODS: RESULTS: We observed an increase in brain DAT after donor FMT compared to oral butyrate that reduced this binding. However, no effect on body weight and insulin sensitivity was demonstrated after post-RYGB donor feces transfer in humans with metabolic syndrome. Increases in fecal levels of Bacteroides uniformis were significantly associated with an increase in DAT, whereas increases in Prevotella spp. showed an inverse association. Changes in the plasma metabolites glycine, betaine, methionine, and lysine (associated with the S-adenosylmethionine cycle) were also associated with altered striatal DAT expression. CONCLUSIONS: Although more and larger studies are needed, our data suggest a potential gut microbiota-driven modulation of brain dopamine and serotonin transporters in human subjects with obese metabolic syndrome. These data also suggest the presence of a gut-brain axis in humans that can be modulated. NTR REGISTRATION: 4488.
|
Authors | Annick V Hartstra, Valentina Schüppel, Sultan Imangaliyev, Anouk Schrantee, Andrei Prodan, Didier Collard, Evgeni Levin, Geesje Dallinga-Thie, Mariette T Ackermans, Maaike Winkelmeijer, Stefan R Havik, Amira Metwaly, Ilias Lagkouvardos, Anika Nier, Ina Bergheim, Mathias Heikenwalder, Andreas Dunkel, Aart J Nederveen, Gerhard Liebisch, Giulia Mancano, Sandrine P Claus, Alfonso Benítez-Páez, Susanne E la Fleur, Jacques J Bergman, Victor Gerdes, Yolanda Sanz, Jan Booij, Elles Kemper, Albert K Groen, Mireille J Serlie, Dirk Haller, Max Nieuwdorp |
Journal | Molecular metabolism
(Mol Metab)
Vol. 42
Pg. 101076
(12 2020)
ISSN: 2212-8778 [Electronic] Germany |
PMID | 32916306
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2020 The Author(s). Published by Elsevier GmbH.. All rights reserved. |
Chemical References |
- Butyrates
- Dopamine Plasma Membrane Transport Proteins
- Insulin
- Serotonin Plasma Membrane Transport Proteins
|
Topics |
- Aged
- Butyrates
(pharmacology)
- Cerebral Cortex
(metabolism)
- Dopamine Plasma Membrane Transport Proteins
(metabolism)
- Double-Blind Method
- Fecal Microbiota Transplantation
(methods)
- Feces
(microbiology)
- Female
- Gastrointestinal Microbiome
- Humans
- Insulin
(metabolism)
- Insulin Resistance
(physiology)
- Male
- Metabolic Syndrome
(metabolism, microbiology, therapy)
- Microbiota
- Middle Aged
- Obesity
(metabolism)
- Serotonin Plasma Membrane Transport Proteins
(metabolism)
|