Abstract | OBJECTIVE: MATERIALS AND METHODS: We performed a systematic review of the literature regarding the use of lopinavir/ ritonavir for the treatment of these three infections. We systematically searched the PubMed database from inception to April 30th, 2020, to identify in-vitro and animal studies and any reports of human use of lopinavir/ ritonavir for the treatment of SARS, MERS and COVID-19. We also searched the Clinicatrial.gov to identify ongoing trials. RESULTS: CONCLUSIONS:
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Authors | M Vargas, G Servillo, S Einav |
Journal | European review for medical and pharmacological sciences
(Eur Rev Med Pharmacol Sci)
Vol. 24
Issue 16
Pg. 8592-8605
(08 2020)
ISSN: 2284-0729 [Electronic] Italy |
PMID | 32894567
(Publication Type: Journal Article, Systematic Review)
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Chemical References |
- Antiviral Agents
- Lopinavir
- Ritonavir
|
Topics |
- Antiviral Agents
(therapeutic use)
- Betacoronavirus
(isolation & purification)
- COVID-19
- Clinical Studies as Topic
- Coronavirus Infections
(drug therapy, pathology, virology)
- Databases, Factual
- Humans
- Lopinavir
(therapeutic use)
- Middle East Respiratory Syndrome Coronavirus
(drug effects, metabolism)
- Pandemics
- Pneumonia, Viral
(drug therapy, pathology, virology)
- Ritonavir
(therapeutic use)
- SARS-CoV-2
- Severe Acute Respiratory Syndrome
(drug therapy, pathology)
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