Comparison of the characteristics of patients with invasive infections and noninvasive infections caused by Trichosporon asahii.

Abstract

We performed retrospective study to identify the characteristics of invasive Trichosporon asahii infection. A total of 102 patients with T. asahii were identified including 18 (18%) with invasive infection. Invasive infection was associated with indwelling central venous catheter (94% vs 54%, P = .001), prior antifungal agent use (50% vs 18%, P = .01), hematologic malignancy (33% vs 7%, P = .006), and end-stage renal disease (28% vs 7%, P = .02). Patients with invasive infections had higher in-hospital mortality than patients with noninvasive infections (61% vs 27%, P = .006). Those with the above risk factors should be monitored for the development of invasive T. asahii infection.

LAY SUMMARY:

Patients with indwelling central venous catheter, prior antifungal agent use, hematologic malignancy, and end-stage renal disease were associated with invasive Trichosporon asahii infection. Patients with invasive infections had higher in-hospital mortality than patients without invasive infection.

• Authors: Jinyeong Kim, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Ho Choi, Sang-Oh Lee, Jun Hee Woo, Yang Soo Kim, Jiwon Jung
• Journal: Medical mycology (Med Mycol) Vol. 59 Issue 3 Pg. 296-300 (Mar 04 2021) ISSN: 1460-2709 [Electronic] England
• PMID: 32876327 (Publication Type: Comparative Study, Journal Article)
• Copyright: © The Author 2020. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.

Chemical References

• Antifungal Agents

Topics

• Aged
• Antifungal Agents (therapeutic use)
• Basidiomycota (pathogenicity)
• Female
• Fungemia (microbiology, mortality)
• Hospital Mortality
• Humans
• Immunocompromised Host
• Male
• Middle Aged
• Retrospective Studies
• Risk Factors
• Trichosporonosis (blood, drug therapy, microbiology, mortality)