One-year results of anti-vascular endothelial growth factor therapy combined with triamcinolone acetonide for macular edema associated with branch retinal vein occlusion.

Abstract

PURPOSE:

To compare anti-vascular endothelial growth factor (anti-VEGF) monotherapy with anti-VEGF therapy combined with sub-Tenon's capsule injections of triamcinolone acetonide (STTA) in patients with macular edema (ME) associated with branch retinal vein occlusion (BRVO).

STUDY DESIGN:

Retrospective observational study METHODS: This study included 186 eyes: 138 eyes received intravitreal injection of ranibizumab (IVR), and the remaining 48 eyes received IVR combined with STTA therapy. If additional IVR were necessary, STTA were performed simultaneously.

RESULTS:

Both groups showed a rapid reduction in ME. The changes in logMAR visual acuity (VA) from baseline to 12 months were - 0.26 ± 0.26 in the IVR and - 0.20 ± 0.26 in the IVR with STTA groups (P = 0.209). The changes in mean central foveal thickness from baseline to 12 months were - 226.9 ± 208.2 µm in the IVR and - 236.0 ± 214.0 µm in the IVR with STTA groups (P = 0.798). The required number of IVR was 3.4 ± 1.9 in the IVR group, and 3.4 ± 1.6 in the IVR and STTA group (P = 0.950). There were no significant differences in any parameters between the two groups.

CONCLUSION:

There were no clear differences between combination therapy of anti-VEGF with STTA and anti-VEGF monotherapy for the treatment of patients with ME associated with BRVO. The number of anti-VEGF injections in patients who received the combination therapy was not reduced as compared with the number of anti-VEGF injections in patients who received the monotherapy.

• Authors: Rie Osaka, Yuki Muraoka, Yuki Nakano, Yukari Takasago, Yuta Koyama, Yukiko Miyoshi, Akitaka Tsujikawa, Kiyoshi Suzuma
• Journal: Japanese journal of ophthalmology (Jpn J Ophthalmol) Vol. 64 Issue 6 Pg. 605-612 (Nov 2020) ISSN: 1613-2246 [Electronic] Japan
• PMID: 32856208 (Publication Type: Journal Article, Observational Study)

Chemical References

• Triamcinolone Acetonide
• Ranibizumab

Topics

• Humans
• Intravitreal Injections
• Macular Edema (diagnosis, drug therapy, etiology)
• Ranibizumab (therapeutic use)
• Retinal Vein Occlusion (complications, diagnosis, drug therapy)
• Retrospective Studies
• Tomography, Optical Coherence
• Treatment Outcome
• Triamcinolone Acetonide (therapeutic use)